Effect of a New Prokinetic Agent DA-9701 Formulated with Corydalis Tuber and Pharbitidis Semen on Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes

Table 3

Effects of DA-9701, Corydalis tuber extract, and Pharbitidis semen extract on UGT metabolic activity in pooled human liver microsomes, H161.

UGT	Marker enzyme	IC50 (𝜇g/mL)
		DA-9701	Corydalis tuber extract	Pharbitidis semen extract
UGT1A1	Etoposide glucuronidation	188	290	No inhibition*
UGT1A4	Trifluoperazine N-glucuronidation	No inhibition	No inhibition	No inhibition
UGT1A9	Propofol glucuronidation	No inhibition	No inhibition	No inhibition
UGT2B7	Azidothymidine glucuronidation	No inhibition	No inhibition	No inhibition

*There was no inhibition at 200 𝜇g/mL of DA-9701, Corydalis tuber extract, and Pharbitidis semen extract. The data represent the average of duplicate analysis.