- About this Journal
- Abstracting and Indexing
- Aims and Scope
- Annual Issues
- Article Processing Charges
- Articles in Press
- Author Guidelines
- Bibliographic Information
- Citations to this Journal
- Contact Information
- Editorial Board
- Editorial Workflow
- Free eTOC Alerts
- Publication Ethics
- Reviewers Acknowledgment
- Submit a Manuscript
- Subscription Information
- Table of Contents
Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 656150, 11 pages
doi:10.1155/2012/656150
Guizhi-Fuling-Wan, a Traditional Chinese Herbal Medicine, Ameliorates Memory Deficits and Neuronal Apoptosis in the Streptozotocin-Induced Hyperglycemic Rodents via the Decrease of Bax/Bcl2 Ratio and Caspase-3 Expression
1Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 40402, Taiwan
2Department of Pharmacology, College of Medicine, China Medical University, Taichung 40402, Taiwan
3Department of Pharmacy, China Medical University Hospital, Taichung 40421, Taiwan
4Department of Pharmacology, University of Minnesota and Geriatric Research, Education and Clinical Center, VA Medical Center, Minneapolis, MN 55455, USA
Received 14 July 2012; Revised 24 September 2012; Accepted 8 October 2012
Academic Editor: Shuang-En Chuang
Copyright © 2012 Kuo-Jen Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- A. A. F. Sima, H. Kamiya, and Z. G. Li, “Insulin, C-peptide, hyperglycemia, and central nervous system complications in diabetes,” European Journal of Pharmacology, vol. 490, no. 1–3, pp. 187–197, 2004. View at Publisher · View at Google Scholar · View at Scopus
- Z. G. Li, W. Zhang, G. Grunberger, and A. A. F. Sima, “Hippocampal neuronal apoptosis in type 1 diabetes,” Brain Research, vol. 946, no. 2, pp. 221–231, 2002. View at Publisher · View at Google Scholar · View at Scopus
- S. M. Zola-Morgan and L. R. Squire, “The primate hippocampal formation: evidence for a time-limited role in memory storage,” Science, vol. 250, no. 4978, pp. 288–290, 1990. View at Scopus
- S. M. Courtney, L. Petit, J. M. Maisog, L. G. Ungerleider, and J. V. Haxby, “An area specialized for spatial working memory in human frontal cortex,” Science, vol. 279, no. 5355, pp. 1347–1351, 1998. View at Publisher · View at Google Scholar · View at Scopus
- Z. A. Ma, Z. Zhao, and J. Turk, “Mitochondrial dysfunction and beta-cell failure in type 2 diabetes mellitus,” Experimental Diabetes Research, vol. 2012, Article ID 703538, 11 pages, 2012. View at Publisher · View at Google Scholar
- A. Baraka and H. Abdelgawad, “Targeting apoptosis in the heart of streptozotocin-induced diabetic rats,” Journal of Cardiovascular Pharmacology and Therapeutics, vol. 15, no. 2, pp. 175–181, 2010. View at Publisher · View at Google Scholar · View at Scopus
- P. C. Waldmeier and W. G. Tatton, “Interrupting apoptosis in neurodegenerative disease: potential for effective therapy?” Drug Discovery Today, vol. 9, no. 5, pp. 210–218, 2004. View at Publisher · View at Google Scholar · View at Scopus
- A. H. Wyllie, “Apoptosis: an overview,” British Medical Bulletin, vol. 53, no. 3, pp. 451–465, 1997. View at Scopus
- D. R. Green and J. C. Reed, “Mitochondria and apoptosis,” Science, vol. 281, no. 5381, pp. 1309–1312, 1998. View at Scopus
- I. Jafari Anarkooli, M. Sankian, S. Ahmadpour, A. R. Varasteh, and H. Haghir, “Evaluation of Bcl-2 family gene expression and Caspase-3 activity in hippocampus STZ-induced diabetic rats,” Experimental Diabetes Research, vol. 2008, Article ID 638467, 6 pages, 2008. View at Publisher · View at Google Scholar · View at Scopus
- X. Ji, J. Gao, X. Cai et al., “Immunological regulation of Chinese herb Guizhi Fuling Capsule on rat endometriosis model,” Journal of Ethnopharmacology, vol. 134, no. 3, pp. 624–629, 2011. View at Publisher · View at Google Scholar · View at Scopus
- Z. Yao and Z. Shulan, “Inhibition effect of Guizhi-Fuling-decoction on the invasion of human cervical cancer,” Journal of Ethnopharmacology, vol. 120, no. 1, pp. 25–35, 2008. View at Publisher · View at Google Scholar · View at Scopus
- Y. Shimada, K. Yokoyama, H. Goto et al., “Protective effect of Keishi-bukuryo-gan and its constituent medicinal plants against nitric oxide donor-induced neuronal death in cultured cerebellar granule cells,” Phytomedicine, vol. 11, no. 5, pp. 404–410, 2004. View at Publisher · View at Google Scholar · View at Scopus
- H.-Y. Ju, S. C. Chen, K.-J. Wu et al., “Antioxidant phenolic profile from ethyl acetate fraction of Fructus Ligustri Lucidi with protection against hydrogen peroxide-induced oxidative damage in SH-SY5Y cells,” Food and Chemical Toxicology, vol. 50, no. 3-4, pp. 492–502, 2012. View at Publisher · View at Google Scholar · View at Scopus
- K. K. Wu and Y. Huan, “Streptozotocin-induced diabetic models in mice and rats,” Current Protocols in Pharmacology, supplement 40, pp. 5.47.1–5.47.14, 2008. View at Publisher · View at Google Scholar · View at Scopus
- R. Morris, “Developments of a water-maze procedure for studying spatial learning in the rat,” Journal of Neuroscience Methods, vol. 11, no. 1, pp. 47–60, 1984. View at Publisher · View at Google Scholar · View at Scopus
- K. J. Wu, M. T. Hsieh, C. R. Wu, W. G. Wood, and Y. F. Chen, “Green tea extract ameliorates learning and memory deficits in ischemic rats via its active component polyphenol epigallocatechin-3-gallate by modulation of oxidative stress and neuroinflammation,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 163106, 11 pages, 2012. View at Publisher · View at Google Scholar
- T. Nakagawa, T. Yokozawa, K. Terasawa, and K. Nakanishi, “Therapeutic usefulness of Keishi-bukuryo-gan for diabetic nephropathy,” Journal of Pharmacy and Pharmacology, vol. 55, no. 2, pp. 219–227, 2003. View at Publisher · View at Google Scholar · View at Scopus
- H. Goto, Y. Shimada, N. Sekiya et al., “Effects of Keishi-bukuryo-gan on vascular function and hemorheological factors in spontaneously diabetic (WBN/kob) rats,” Phytomedicine, vol. 11, no. 2-3, pp. 188–195, 2004. View at Publisher · View at Google Scholar · View at Scopus
- D. L. Brody and D. M. Holtzman, “Morris water maze search strategy analysis in PDAPP mice before and after experimental traumatic brain injury,” Experimental Neurology, vol. 197, no. 2, pp. 330–340, 2006. View at Publisher · View at Google Scholar · View at Scopus
- C. R. Wu, L. W. Lin, C. L. Hsieh, W. H. Wang, Y. T. Lin, and M. T. Hsieh, “Petroleum ether extract of Cnidium monnieri ameliorated scopolamine-induced amnesia through adrenal gland-mediated mechanism in male rats,” Journal of Ethnopharmacology, vol. 117, no. 3, pp. 403–407, 2008. View at Publisher · View at Google Scholar · View at Scopus
- G. J. Biessels, A. Kamal, I. J. A. Urban, B. M. Spruijt, D. W. Erkelens, and W. H. Gispen, “Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: effects of insulin treatment,” Brain Research, vol. 800, no. 1, pp. 125–135, 1998. View at Publisher · View at Google Scholar · View at Scopus
- Y. Revsin, N. V. Rekers, M. C. Louwe et al., “Glucocorticoid receptor blockade normalizes hippocampal alterations and cognitive impairment in streptozotocin-induced type 1 diabetes mice,” Neuropsychopharmacology, vol. 34, no. 3, pp. 747–758, 2009. View at Publisher · View at Google Scholar · View at Scopus
- S. Brecht, M. Gelderblom, A. Srinivasan, K. Mielke, G. Dityateva, and T. Herdegen, “Caspase-3 activation and DNA fragmentation in primary hippocampal neurons following glutamate excitotoxicity,” Molecular Brain Research, vol. 94, no. 1-2, pp. 25–34, 2001. View at Publisher · View at Google Scholar · View at Scopus
- D. R. Green, “Apoptotic pathways: paper wraps stone blunts scissors,” Cell, vol. 102, no. 1, pp. 1–4, 2000. View at Scopus
- Z. G. Li, M. Britton, A. A. F. Sima, and J. C. Dunbar, “Diabetes enhances apoptosis induced by cerebral ischemia,” Life Sciences, vol. 76, no. 3, pp. 249–262, 2004. View at Publisher · View at Google Scholar · View at Scopus
- M. O. Hengartner, “The biochemistry of apoptosis,” Nature, vol. 407, no. 6805, pp. 770–776, 2000. View at Publisher · View at Google Scholar · View at Scopus