Research Article

Mechanism of Earthquake Simulation as a Prenatal Stressor Retarding Rat Offspring Development and Chinese Medicine Correcting the Retardation: Hormones and Gene-Expression Alteration

Table 4

Significant GO annotation of the 120 differentially expressed genes and the genes involved ( ).

GO IdNameSymbolHitsTotalPercentEnrichment test value

GO: 0016874Ligase activityUbe2n, Hlcs
Gart, Herc1,73082.27%0.0083
Cul5, Rnf168, Ggcx

GO: 0019222Regulation of metabolic processSqstm1, Insl3, Ube2n, Pou4f2,
Otx1, Cnot6, Tinf2,
RGD1562997, Irf7,
Tspyl2, Nrip1, 2824151.16%0.0089
Zscan21, Jarid1b, Bcl11b, Dyrk2,
Mll1, Rfx7, Zfp422, Smek2, Suv420h1, Elf2, Cdk2, Hdac4, Impact,
Foxj2, Rasd1, Rnf168, Pfn2

GO: 0009893Positive regulation of metabolic processSqstm1, Insl3, Ube2n,
Pou4f2, Tinf2,
Nrip1, Zscan21, Bcl11b138461.54%0.0098
Dyrk2, Mll1, Cdk2
Hdac4, Rnf168

GO: 0022607Cellular component assemblySqstm1, Xtp3tpa
Vamp2, Cox18, Tinf2, Eif3s10, RGD1562997127861.53%0.0135
Srpk2, Mll1, Enth, Pfn2

GO: 0043227Membrane-bounded organelleSqstm1, Crcp, Ube2n, Mutyh, Pou4f2, Vamp2
Itpr1, Otx1, Cnot6
Hlcs, Cox18, Tinf2
Isca1, Eif3s10
RGD1562997
Irf7, Srpk2, Ikzf3
Ppp2r5e, Yipf3
Tspyl2, Zrsr2, Nrip1
Zscan21, Kif20b
Visa, RGD15655915559820.92%0.025
Bcl11b, Dyrk2
Slc25a32, Mll1, Enth
B3gnt7, Zfp422, Setx
Suv420h1, Elf2, Phf3
Cdk2, Adck5, Hdac4 Hcr, LOC498145
Pdcd6ip, Foxj2, Rasd1, Resp18, Cul5
Cacnb1,Timm17a,
Arc, Rnf168, Cog2,
Itpr2, Ggcx

GO: 0014854Response to inactivityHdac41333.33%0.0288

GO: 0009058Biosynthetic processCrcp, Insl3,Ube2n
Mat2a, Pou4f2, Otx1
Cnot6, Gart, Tinf2
Isca1, RGD1562997
Eif3s10, Irf7, Coq6
Tspyl2, Nrip1, Mll13433791.01%0.0291
Zscan21, Jarid1b
Bcl11b, Dyrk2, Rfx7
B3gnt7, Zfp422, Elf2
Suv420h1, Cdk2, Phf3
Hdac4, Impact, Foxj2
Rabggta, Rasd1

GO: 0044085Cellular component biogenesisSqstm1, Xtp3tpa,
Vamp2, Cox18, Tinf2
RGD1562997, Eif3s10128831.36%0.0299
Srpk2, Mll1, Enth, Pfn2

GO: 0014874Response to stimulus involved in regulation of muscle adaptationHdac41425.00%0.0359

GO: 0043233Organelle lumenSqstm1, Mutyh, Itpr1
Tinf2, RGD1562997
Srpk2, Tspyl2, Zrsr21613601.18%0.0416
Nrip1, Kif20b, Mll1
Zfp422, Setx, Cdk2
Hdac4, Resp18

GO: 0051716Cellular response to stimulusUbe2n, Mutyh, Dyrk2
Mll1, Setx, Cdk2, 85281.52%0.0422
Pdcd6ip, Rnf168

GO: 0016740Transferase activityCrcp, Mat2a, Pfkfb2
Gart, Mgst2, Srpk2
RGD1304822, Dyrk21816121.12%0.0483
Fastkd1, Mll1, B3gnt7
Suv420h1, Cdk2, Fgfr1l, RGD1560523
Rabggta, Csnk1g1

GO: 0031974Membrane enclosed lumenSqstm1, Mutyh, Itpr1
Tinf2, RGD1562997
Srpk2, Tspyl2, Zrsr2
Nrip1, Kif20b, Mll11613921.15%0.0495
Zfp422, Setx, Cdk2,
Hdac4, Resp18

GO: 0031077Postembryonic camera-type eye developmentBcl11b1616.67%0.0499