Effects of Different Electroacupuncture Scheduling Regimens on Murine Bone Tumor-Induced Hyperalgesia: Sex Differences and Role of Inflammation

Figure 6

Mean PGE₂ concentration in pg/mL as measured by ELISA from fibrosarcoma tumor microperfusate samples (𝑛=3/group). Data are expressed as mean ± SEM. Mean tumor PGE₂ concentration significantly decreased following application of EA-2X beginning at PID 3. In addition, EA reduced the PGE₂ concentration in saline injected control animals. Mean PGE₂ concentrations for Saline, Tumor, Sal + EA-2X and Tumor + EA-2X were 265.80±0.20, 309.20±16.33, 225.20±12.80, and 135.20±4.36, respectively (*𝑃<0.05, Saline + EA-2X versus Tumor + EA-2X; *𝑃<0.05, Tumor versus Tumor + EA-2X; *𝑃<0.05, Saline versus Sal + EA-2X).