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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 678592, 10 pages
Citrus ichangensis Peel Extract Exhibits Anti-Metabolic Disorder Effects by the Inhibition of PPAR and LXR Signaling in High-Fat Diet-Induced C57BL/6 Mouse
1College of Horticulture and Landscape Architecture, Southwest University, Chongqing 400716, China
2Key Laboratory of Horticulture Science for Southern Mountainous Regions, Ministry of Education, Chongqing 400715, China
3School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China
4Citrus Research Institute, Chinese Academy of Agricultural Sciences, Chongqing 400712, China
5Scientific Experimental Center, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China
Received 7 October 2012; Accepted 29 November 2012
Academic Editor: Weena Jiratchariyakul
Copyright © 2012 Xiaobo Ding et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- W.H. Organization, “Obesity and overweight,” 2011, http://www.who.int/mediacentre/factsheets/fs311/en/index.html.
- C. J. Lavie, R. V. Milani, and H. O. Ventura, “Obesity and cardiovascular disease. Risk factor, paradox, and impact of weight loss,” Journal of the American College of Cardiology, vol. 53, no. 21, pp. 1925–1932, 2009.
- J. D. Fernstrom and S. Choi, “The development of tolerance to drugs that suppress food intake,” Pharmacology and Therapeutics, vol. 117, no. 1, pp. 105–122, 2008.
- Z. Li, M. Maglione, W. Tu et al., “Meta-analysis: pharmacologic treatment of obesity,” Annals of Internal Medicine, vol. 142, no. 7, pp. 532–546, 2005.
- N. Vasudeva, N. Yadav, and S. K. Sharma, “Natural products: a safest approach for obesity,” Chinese Journal of Integrative Medicine, vol. 18, no. 6, pp. 473–480, 2012.
- M. Choudhary and K. Grover, “Development of functional food products in relation to obesity,” Functional Foods in Health and Disease, vol. 2, pp. 188–197, 2012.
- U. J. Jung, H. J. Kim, J. S. Lee et al., “Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects,” Clinical Nutrition, vol. 22, no. 6, pp. 561–568, 2003.
- S. Gorinstein, A. Caspi, I. Libman et al., “Red grapefruit positively influences serum triglyceride level in patients suffering from coronary atherosclerosis: studies in vitro and in humans,” Journal of Agricultural and Food Chemistry, vol. 54, no. 5, pp. 1887–1892, 2006.
- D. E. Okwu, “Citrus fruits: a rich source of phytochemicals and their roles in human health,” International Journal of Chemical Sciences, vol. 6, pp. 451–471, 2008.
- T. Tanaka, M. Tanaka, and T. Kuno, “Cancer chemoprevention by citrus pulp and juices containing high amounts of beta-cryptoxanthin and hesperidin,” Journal of Biomedicine and Biotechnology, vol. 2012, Article ID 516981, 10 pages, 2012.
- T. Yamada, S. Hayasaka, Y. Shibata et al., “Frequency of citrus fruit intake is associated with the incidence of cardiovascular disease: the Jichi medical school cohort study,” Journal of Epidemiology, vol. 21, no. 3, pp. 169–175, 2011.
- H. G. Preuss, D. DiFerdinando, M. Bagchi, and D. Bagchi, “Citrus aurantium as a thermogenic, weight-reduction replacement for eprhedra: an overview,” Journal of Medicine, vol. 33, no. 1–4, pp. 247–264, 2002.
- S. J. Wu, C. C. Ng, W. S. Tzeng, K. C. Ho, and Y. T. Shyu, “Functional antioxidant and tyrosinase inhibitory properties of extracts of Taiwanese pummelo (Citrus grandis Osbeck),” African Journal of Biotechnology, vol. 10, no. 39, pp. 7668–7674, 2011.
- H. S. Shin, S. I. Kang, H. C. Ko et al., “Anti-inflammatory effect of the immature peel extract of Jinkyool (Citrus sunki Hort. ex Tanaka),” Food Science and Biotechnology, vol. 20, no. 5, pp. 1235–1241, 2011.
- J. A. Manthey and K. Grohmann, “Phenols in citrus peel byproducts. Concentrations of hydroxycinnamates and polymethoxylated flavones in citrus peel molasses,” Journal of Agricultural and Food Chemistry, vol. 49, no. 7, pp. 3268–3273, 2001.
- F. Neville, N. A. Pchelintsev, M. J. F. Broderick, T. Gibson, and P. A. Millner, “Novel one-pot synthesis and characterization of bioactive thiol-silicate nanoparticles for biocatalytic and biosensor applications,” Nanotechnology, vol. 20, no. 5, Article ID 055612, 2009.
- S.P. Committee, Chinese Pharmacopoeia, Chemical Industry Press, Beijing, China, 2005.
- H. K. Jung, Y. S. Jeong, C. D. Park, C. H. Park, and J. H. Hong, “Inhibitory effect of citrus peel extract on lipid accumulation of 3T3-L1 adipocytes,” Journal of Applied Biological Chemistry, vol. 54, no. 2, pp. 169–176, 2011.
- T. Tsujita and T. Takaku, “Lipolysis induced by segment wall extract from Satsuma mandarin orange (Citrus unshu Mark),” Journal of Nutritional Science and Vitaminology, vol. 53, no. 6, pp. 547–551, 2007.
- S. H. Bok, S. H. Lee, Y. B. Park et al., “Plasma and hepatic cholesterol and hepatic activities of 3-hydroxy-3- methyl-glutaryl-CoA reductase and acyl CoA: cholesterol transferase are lower in rats fed citrus peel extract or a mixture of citrus bioflavonoids,” Journal of Nutrition, vol. 129, no. 6, pp. 1182–1185, 1999.
- S. I. Kang, H. S. Shin, H. M. Kim et al., “Immature Citrus sunki peel extract exhibits antiobesity effects by beta-oxidation and lipolysis in high-fat diet-induced obese mice,” Biological and Pharmaceutical Bulletin, vol. 35, no. 2, pp. 223–230, 2012.
- S. Haaz, K. R. Fontaine, G. Cutter, N. Limdi, S. Perumean-Chaney, and D. B. Allison, “Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: an update,” Obesity Reviews, vol. 7, no. 1, pp. 79–88, 2006.
- E. Ono, J. Inoue, T. Hashidume, M. Shimizu, and R. Sato, “Anti-obesity and anti-hyperglycemic effects of the dietary citrus limonoid nomilin in mice fed a high-fat diet,” Biochemical and Biophysical Research Communications, vol. 410, no. 3, pp. 677–681, 2011.
- K. Nagao, N. Yamano, B. Shirouchi et al., “Effects of citrus auraptene (7-Geranyloxycoumarin) on hepatic lipid metabolism in vitro and in vivo,” Journal of Agricultural and Food Chemistry, vol. 58, no. 16, pp. 9028–9032, 2010.
- E. E. Mulvihill and M. W. Huff, “Protection from metabolic dysregulation, obesity, and atherosclerosis by citrus flavonoids: activation of hepatic PGC1α-mediated fatty acid oxidation,” PPAR Research, vol. 2012, Article ID 857142, 9 pages, 2012.
- J. Goldwasser, P. Y. Cohen, E. Yang, P. Balaguer, M. L. Yarmush, and Y. Nahmias, “Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARα, PPARγ and LXRα,” PLoS ONE, vol. 5, no. 8, Article ID e12399, 2010.
- C. H. Lee, P. Olson, and R. M. Evans, “Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors,” Endocrinology, vol. 144, no. 6, pp. 2201–2207, 2003.
- R. M. Evans, G. D. Barish, and Y. X. Wang, “PPARs and the complex journey to obesity,” Nature Medicine, vol. 10, no. 4, pp. 355–361, 2004.
- R. Pakala, S. W. Rha, P. K. Kuchulakanti, E. Cheneau, R. Baffour, and R. Waksman, “Peroxisome proliferator-activated receptor γ: its role in atherosclerosis and restenosis,” Cardiovascular Radiation Medicine, vol. 5, no. 1, pp. 44–48, 2004.
- K. W. Cho, Y. O. Kim, J. E. Andrade, J. R. Burgess, and Y. C. Kim, “Dietary naringenin increases hepatic peroxisome proliferators-activated receptor α protein expression and decreases plasma triglyceride and adiposity in rats,” European Journal of Nutrition, vol. 50, no. 2, pp. 81–88, 2011.
- G. S. Kim, H. J. Park, J. H. Woo et al., “Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells,” BMC Complementary and Alternative Medicine, vol. 12, article 31, 2012.
- R. W. Li, A. G. Theriault, K. Au et al., “Citrus polymethoxylated flavones improve lipid and glucose homeostasis and modulate adipocytokines in fructose-induced insulin resistant hamsters,” Life Sciences, vol. 79, no. 4, pp. 365–373, 2006.
- E. M. Kurowska, J. A. Manthey, A. Casaschi, and A. G. Theriault, “Modulation of HepG2 cell net apolipoprotein B secretion by the citrus polymethoxyflavone, tangeretin,” Lipids, vol. 39, no. 2, pp. 143–151, 2004.
- A. K. Sharma, S. Bharti, S. Ojha et al., “Up-regulation of PPARγ, heat shock protein-27 and -72 by naringin attenuates insulin resistance, β-cell dysfunction, hepatic steatosis and kidney damage in a rat model of type 2 diabetes,” British Journal of Nutrition, vol. 106, no. 11, pp. 1713–1723, 2011.
- P. Spiegel-Roy and E. E. Goldschmidt, Biology of Citrus, Cambridge University Press, New York, NY, USA, 1996.
- Z. Herman, S. Hasegawa, C. H. Fong, and P. Ou, “Limonoids in Citrus ichangensis,” Journal of Agricultural and Food Chemistry, vol. 37, no. 4, pp. 850–851, 1989.
- T. H. Chun, M. Inoue, H. Morisaki et al., “Genetic link between obesity and MMP14-dependent adipogenic collagen turnover,” Diabetes, vol. 59, no. 10, pp. 2484–2494, 2010.
- J. D. McGarry and D. W. Foster, “Regulation of hepatic fatty acid oxidation and ketone body production,” Annual Review of Biochemistry, vol. 49, pp. 395–420, 1980.
- J. K. Kim, O. Gavrilova, Y. Chen, M. L. Reitman, and G. I. Shulman, “Mechanism of insulin resistance in A-ZIP/F-1 fatless mice,” The Journal of Biological Chemistry, vol. 275, no. 12, pp. 8456–8460, 2000.
- M. S. Choi, K. M. Do, Y. B. Park et al., “Effect of naringin supplementation on cholesterol metabolism and antioxidant status in rats fed high cholesterol with different levels of vitamin E,” Annals of Nutrition and Metabolism, vol. 45, no. 5, pp. 193–201, 2001.
- U. J. Jung, M. K. Lee, Y. B. Park, M. A. Kang, and M. S. Choi, “Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice,” International Journal of Biochemistry and Cell Biology, vol. 38, no. 7, pp. 1134–1145, 2006.
- U. J. Jung, M. K. Lee, K. S. Jeong, and M. S. Choi, “The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice,” Journal of Nutrition, vol. 134, no. 10, pp. 2499–2503, 2004.
- S. Akiyama, S. I. Katsumata, K. Suzuki, Y. Ishimi, J. Wu, and M. Uehara, “Dietary hesperidin exerts hypoglycemic and hypolipidemic effects in streptozotocin-induced marginal type 1 diabetic rats,” Journal of Clinical Biochemistry and Nutrition, vol. 46, no. 1, pp. 87–92, 2010.
- H. Y. Yoon, S. I. Yun, B. Y. Kim et al., “Poncirin promotes osteoblast differentiation but inhibits adipocyte differentiation in mesenchymal stem cells,” European Journal of Pharmacology, vol. 664, no. 1–3, pp. 54–59, 2011.
- Y. Zhang, S. Fan, N. Hu et al., “Rhein reduces fat weight in db/db mouse and prevents diet-induced obesity in C57Bl/6 mouse through the inhibition of PPARγ signaling,” PPAR Research, vol. 2012, Article ID 374936, 9 pages, 2012.
- Z. Gong, C. Huang, X. Sheng et al., “The role of Tanshinone IIA in the treatment of obesity through peroxisome proliferator-activated receptor γ antagonism,” Endocrinology, vol. 150, no. 1, pp. 104–113, 2009.
- N. Mitro, P. A. Mak, L. Vargas et al., “The nuclear receptor LXR is a glucose sensor,” Nature, vol. 445, no. 7124, pp. 219–223, 2007.