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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 684510, 26 pages
http://dx.doi.org/10.1155/2012/684510
Review Article

Vitamin E and the Healing of Bone Fracture: The Current State of Evidence

Pharmacoepidemiology and Drug Safety Unit, Department of Pharmacology, Faculty of Medicine, National University of Malaysia, Jalan Raja Muda Abd Aziz, 50300 Kuala Lumpur, Malaysia

Received 4 June 2012; Revised 26 July 2012; Accepted 26 July 2012

Academic Editor: Ahmad Nazrun Shuid

Copyright © 2012 Boekhtiar Borhanuddin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Castellini, E. Mourvaki, A. Dal Bosco, and F. Galli, “Vitamin E biochemistry and function: a case study in male rabbit,” Reproduction in Domestic Animals, vol. 42, no. 3, pp. 248–256, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. M. W. Clarke, J. R. Burnett, and K. D. Croft, “Vitamin E in human health and disease,” Critical Reviews in Clinical Laboratory Sciences, vol. 45, no. 5, pp. 417–450, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. B. B. Aggarwal, C. Sundaram, S. Prasad, and R. Kannappan, “Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases,” Biochemical Pharmacology, vol. 80, no. 11, pp. 1613–1631, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. I. S. Young and J. V. Woodside, “Antioxidants in health and disease,” Journal of Clinical Pathology, vol. 54, no. 3, pp. 176–186, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Azzi, R. Gysin, P. Kempná et al., “Regulation of gene expression by α-tocopherol,” Biological Chemistry, vol. 385, no. 7, pp. 585–591, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Fujita, M. Iwasaki, H. Ochi et al., “Vitamin E decreases bone mass by stimulating osteoclast fusion,” Nature Medicine, vol. 18, no. 4, pp. 589–594, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. S. A. Sheweita and K. I. Khoshhal, “Calcium metabolism and oxidative stress in bone fractures: role of antioxidants,” Current Drug Metabolism, vol. 8, no. 5, pp. 519–525, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. M. D. Paskalev, N. V. Goranov, S. J. Krastev, and R. T. Roydev, “Antioxidant and bone healing effect of vitamin E in an experimental osteotomy model in dogs,” Comparative Clinical Pathology, vol. 20, no. 4, pp. 403–408, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. D. Foschi, E. Trabucchi, M. Musazzi et al., “The effects of oxygen free radicals on wound healing,” International Journal of Tissue Reactions, vol. 10, no. 6, pp. 373–379, 1988. View at Scopus
  10. E. Gokturk, A. Turgut, C. Baycu, I. Gunal, S. Seber, and Z. Gulbas, “Oxygen-free radicals impair fracture healing in rats,” Acta Orthopaedica Scandinavica, vol. 66, no. 5, pp. 473–475, 1995. View at Scopus
  11. G. W. Burton and K. U. Ingold, “Vitamin E as an in vitro and in vivo antioxidant,” Annals of the New York Academy of Sciences, vol. 570, pp. 7–22, 1989. View at Scopus
  12. S. A. van Acker, L. M. H. Koymans, and A. Bast, “Molecular pharmacology of vitamin E: structural aspects of antioxidant activity,” Free Radical Biology and Medicine, vol. 15, no. 3, pp. 311–328, 1993. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Maniam, N. Mohamed, A. N. Shuid, and I. N. Soelaiman, “Palm tocotrienol exerted better antioxidant activities in bone than α-tocopherol,” Basic and Clinical Pharmacology and Toxicology, vol. 103, no. 1, pp. 55–60, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. I. G. Needleman, “A guide to systematic reviews,” Journal of Clinical Periodontology, vol. 29, supplement 3, pp. 6–9, 2002. View at Scopus
  15. M. Kurklu, C. Yildiz, O. Kose et al., “Effect of alpha-tocopherol on bone formation during distraction osteogenesis: a rabbit model,” Journal of Orthopaedics and Traumatology, vol. 12, no. 3, pp. 153–158, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. J. M. Lane and H. S. Sandhu, “Current approaches to experimental bone grafting,” Orthopedic Clinics of North America, vol. 18, no. 2, pp. 213–225, 1987. View at Scopus
  17. P. M. Huddleston, J. M. Steckelberg, A. D. Hanssen, M. S. Rouse, M. E. Bolander, and R. Patel, “Ciprofloxacin inhibition of experimental fracture-healing,” Journal of Bone and Joint Surgery. Series A, vol. 82, no. 2, pp. 161–173, 2000. View at Scopus
  18. A. N. Shuid, S. Mohamad, N. Muhammad et al., “Effects of α-tocopherol on the early phase of osteoporotic fracture healing,” Journal of Orthopaedic Research, vol. 29, no. 11, pp. 1732–1738, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. A. N. Shuid, S. Mohamad, N. Mohamed et al., “Effects of calcium supplements on fracture healing in a rat osteoporotic model,” Journal of Orthopaedic Research, vol. 28, no. 12, pp. 1651–1656, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. S. J. Warden, D. E. Komatsu, J. Rydberg, J. L. Bond, and S. M. Hassett, “Recombinant human parathyroid hormone (PTH 1-34) and low-intensity pulsed ultrasound have contrasting additive effects during fracture healing,” Bone, vol. 44, no. 3, pp. 485–494, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. C. Y. Turk, M. Halici, A. Guney, H. Akgun, V. Sahin, and S. Muhtaroglu, “Promotion of fracture healing by vitamin E in rats,” Journal of International Medical Research, vol. 32, no. 5, pp. 507–512, 2004. View at Scopus
  22. H. L. Allen, A. Wase, and W. T. Bear, “Indomethacin and aspirin: effect of nonsteroidal anti-inflammatory agents on the rate of fracture repair in the rat,” Acta Orthopaedica Scandinavica, vol. 51, no. 4, pp. 595–600, 1980. View at Scopus
  23. K. Durak, G. Sonmez, B. Sarisozen, S. Ozkan, M. Kaya, and C. Ozturk, “Histological assessment of the effect of α-tocopherol on fracture healing in rabbits,” Journal of International Medical Research, vol. 31, no. 1, pp. 26–30, 2003. View at Scopus
  24. B. Sarisözen, K. Durak, G. Dinçer, and O. F. Bilgen, “The effects of vitamins E and C on fracture healing in rats,” Journal of International Medical Research, vol. 30, no. 3, pp. 309–313, 2002. View at Scopus
  25. O. O. Oni, J. Dunning, R. J. Mobbs, and P. J. Gregg, “Clinical factors and the size of the external callus in tibial shaft fractures,” Clinical Orthopaedics and Related Research, no. 273, pp. 278–283, 1991. View at Scopus
  26. C. Kilkenny, W. J. Browne, I. C. Cuthill, M. Emerson, and D. G. Altman, “Improving bioscience research reporting: the arrive guidelines for reporting animal research,” PLoS Biology, vol. 8, no. 6, Article ID e1000412, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. B. Prajapati, M. Dunne, and R. Armstrong, “Sample size estimation and statistical power analyses,” Optometry Today, 2010.
  28. G. T. Sica, “Bias in research studies,” Radiology, vol. 238, no. 3, pp. 780–789, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. P. Araujo and L. Frøyland, “Statistical power and analytical quantification,” Journal of Chromatography B, vol. 847, no. 2, pp. 305–308, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. J. Cohen, Statistical Power Analysis for the Behavioral Sciences, Lawrence Erlbaum, NJ, USA, 1988.
  31. P. Cronin, F. Ryan, and M. Coughlan, “Undertaking a literature review: a step-by-step approach,” British Journal of Nursing, vol. 17, no. 1, pp. 38–43, 2008. View at Scopus
  32. L. Claes, S. Recknagel, and A. Ignatius, “Fracture healing under healthy and inflammatory conditions,” Nature Reviews Rheumatology, vol. 8, no. 3, pp. 133–143, 2012. View at Publisher · View at Google Scholar · View at Scopus
  33. K. Durak, O. F. Bilgen, T. Kaleli, P. Tuncel, R. Ozbek, and K. Turan, “Antioxidant effect of α-tocopherol on fracture haematoma in rabbits,” Journal of International Medical Research, vol. 24, no. 5, pp. 419–424, 1996. View at Scopus
  34. N. S. Young, J. P. A. Ioannidis, and O. Al-Ubaydli, “Why current publication practices may distort science,” PLoS Medicine, vol. 5, no. 10, article no. e201, pp. 1418–1422, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. B. Phillips, C. Ball, S. Sackett et al., “Levels of evidence (March 2009),” 2009, http://www.cebm.net/index.aspx?o=1025.
  36. M. Turlik, “Introduction to evidence based medicine,” The Foot & Ankle Journal, vol. 2, no. 2, 2009.
  37. P. Pound, S. Ebrahim, P. Sandercock, M. B. Bracken, and I. Roberts, “Where is the evidence that animal research benefits humans?” British Medical Journal, vol. 328, no. 7438, pp. 514–517, 2004. View at Scopus
  38. V. Bebarta, D. Luyten, and K. Heard, “Emergency medicine animal research: does use of randomization and blinding affect the results?” Academic Emergency Medicine, vol. 10, no. 6, pp. 684–687, 2003. View at Scopus
  39. M. F. W. Festing and D. G. Altman, “Guidelines for the design and statistical analysis of experiments using laboratory animals,” ILAR Journal, vol. 43, no. 4, pp. 244–257, 2002. View at Scopus
  40. C. G. Begley and L. M. Ellis, “Raise standards for preclinical cancer research,” Nature, vol. 483, no. 7391, pp. 531–533, 2012. View at Publisher · View at Google Scholar
  41. A. R. E. N. A. Office of Laboratory Animal Welfare, Institutional Animal Care and Use Committee Guidebook, Office of Laboratory Animal Welfare, Bethesda, MD, USA, 2nd edition, 2002.
  42. W. M. S. Russell and R. L. Burch, The Principles of Humane Experimental Techniques, Methuen & Co, London, 1959.
  43. R. M. Baron and D. A. Kenny, “The moderator-mediator variable distinction in social psychological research. conceptual, strategic, and statistical considerations,” Journal of Personality and Social Psychology, vol. 51, no. 6, pp. 1173–1182, 1986. View at Publisher · View at Google Scholar · View at Scopus
  44. P. A. Frazier, A. P. Tix, and K. E. Barron, “Testing moderator and mediator effects in counseling psychology research,” Journal of Counseling Psychology, vol. 51, no. 1, pp. 115–134, 2004. View at Publisher · View at Google Scholar · View at Scopus
  45. C. M. Lockwood, C. A. DeFrancesco, D. L. Elliot, S. A. A. Beresford, and D. J. Toobert, “Mediation analyses: applications in nutrition research and reading the literature,” Journal of the American Dietetic Association, vol. 110, no. 5, pp. 753–762, 2010. View at Publisher · View at Google Scholar · View at Scopus
  46. R. Armstrong, N. Jackson, J. Doyle, E. Waters, and F. Howes, “It's in your hands: the value of handsearching in conducting systematic reviews of public health interventions,” Journal of Public Health, vol. 27, no. 4, pp. 388–391, 2005. View at Publisher · View at Google Scholar · View at Scopus