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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 684510, 26 pages
Vitamin E and the Healing of Bone Fracture: The Current State of Evidence
Pharmacoepidemiology and Drug Safety Unit, Department of Pharmacology, Faculty of Medicine, National University of Malaysia, Jalan Raja Muda Abd Aziz, 50300 Kuala Lumpur, Malaysia
Received 4 June 2012; Revised 26 July 2012; Accepted 26 July 2012
Academic Editor: Ahmad Nazrun Shuid
Copyright © 2012 Boekhtiar Borhanuddin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- C. Castellini, E. Mourvaki, A. Dal Bosco, and F. Galli, “Vitamin E biochemistry and function: a case study in male rabbit,” Reproduction in Domestic Animals, vol. 42, no. 3, pp. 248–256, 2007.
- M. W. Clarke, J. R. Burnett, and K. D. Croft, “Vitamin E in human health and disease,” Critical Reviews in Clinical Laboratory Sciences, vol. 45, no. 5, pp. 417–450, 2008.
- B. B. Aggarwal, C. Sundaram, S. Prasad, and R. Kannappan, “Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases,” Biochemical Pharmacology, vol. 80, no. 11, pp. 1613–1631, 2010.
- I. S. Young and J. V. Woodside, “Antioxidants in health and disease,” Journal of Clinical Pathology, vol. 54, no. 3, pp. 176–186, 2001.
- A. Azzi, R. Gysin, P. Kempná et al., “Regulation of gene expression by α-tocopherol,” Biological Chemistry, vol. 385, no. 7, pp. 585–591, 2004.
- K. Fujita, M. Iwasaki, H. Ochi et al., “Vitamin E decreases bone mass by stimulating osteoclast fusion,” Nature Medicine, vol. 18, no. 4, pp. 589–594, 2012.
- S. A. Sheweita and K. I. Khoshhal, “Calcium metabolism and oxidative stress in bone fractures: role of antioxidants,” Current Drug Metabolism, vol. 8, no. 5, pp. 519–525, 2007.
- M. D. Paskalev, N. V. Goranov, S. J. Krastev, and R. T. Roydev, “Antioxidant and bone healing effect of vitamin E in an experimental osteotomy model in dogs,” Comparative Clinical Pathology, vol. 20, no. 4, pp. 403–408, 2011.
- D. Foschi, E. Trabucchi, M. Musazzi et al., “The effects of oxygen free radicals on wound healing,” International Journal of Tissue Reactions, vol. 10, no. 6, pp. 373–379, 1988.
- E. Gokturk, A. Turgut, C. Baycu, I. Gunal, S. Seber, and Z. Gulbas, “Oxygen-free radicals impair fracture healing in rats,” Acta Orthopaedica Scandinavica, vol. 66, no. 5, pp. 473–475, 1995.
- G. W. Burton and K. U. Ingold, “Vitamin E as an in vitro and in vivo antioxidant,” Annals of the New York Academy of Sciences, vol. 570, pp. 7–22, 1989.
- S. A. van Acker, L. M. H. Koymans, and A. Bast, “Molecular pharmacology of vitamin E: structural aspects of antioxidant activity,” Free Radical Biology and Medicine, vol. 15, no. 3, pp. 311–328, 1993.
- S. Maniam, N. Mohamed, A. N. Shuid, and I. N. Soelaiman, “Palm tocotrienol exerted better antioxidant activities in bone than α-tocopherol,” Basic and Clinical Pharmacology and Toxicology, vol. 103, no. 1, pp. 55–60, 2008.
- I. G. Needleman, “A guide to systematic reviews,” Journal of Clinical Periodontology, vol. 29, supplement 3, pp. 6–9, 2002.
- M. Kurklu, C. Yildiz, O. Kose et al., “Effect of alpha-tocopherol on bone formation during distraction osteogenesis: a rabbit model,” Journal of Orthopaedics and Traumatology, vol. 12, no. 3, pp. 153–158, 2011.
- J. M. Lane and H. S. Sandhu, “Current approaches to experimental bone grafting,” Orthopedic Clinics of North America, vol. 18, no. 2, pp. 213–225, 1987.
- P. M. Huddleston, J. M. Steckelberg, A. D. Hanssen, M. S. Rouse, M. E. Bolander, and R. Patel, “Ciprofloxacin inhibition of experimental fracture-healing,” Journal of Bone and Joint Surgery. Series A, vol. 82, no. 2, pp. 161–173, 2000.
- A. N. Shuid, S. Mohamad, N. Muhammad et al., “Effects of α-tocopherol on the early phase of osteoporotic fracture healing,” Journal of Orthopaedic Research, vol. 29, no. 11, pp. 1732–1738, 2011.
- A. N. Shuid, S. Mohamad, N. Mohamed et al., “Effects of calcium supplements on fracture healing in a rat osteoporotic model,” Journal of Orthopaedic Research, vol. 28, no. 12, pp. 1651–1656, 2010.
- S. J. Warden, D. E. Komatsu, J. Rydberg, J. L. Bond, and S. M. Hassett, “Recombinant human parathyroid hormone (PTH 1-34) and low-intensity pulsed ultrasound have contrasting additive effects during fracture healing,” Bone, vol. 44, no. 3, pp. 485–494, 2009.
- C. Y. Turk, M. Halici, A. Guney, H. Akgun, V. Sahin, and S. Muhtaroglu, “Promotion of fracture healing by vitamin E in rats,” Journal of International Medical Research, vol. 32, no. 5, pp. 507–512, 2004.
- H. L. Allen, A. Wase, and W. T. Bear, “Indomethacin and aspirin: effect of nonsteroidal anti-inflammatory agents on the rate of fracture repair in the rat,” Acta Orthopaedica Scandinavica, vol. 51, no. 4, pp. 595–600, 1980.
- K. Durak, G. Sonmez, B. Sarisozen, S. Ozkan, M. Kaya, and C. Ozturk, “Histological assessment of the effect of α-tocopherol on fracture healing in rabbits,” Journal of International Medical Research, vol. 31, no. 1, pp. 26–30, 2003.
- B. Sarisözen, K. Durak, G. Dinçer, and O. F. Bilgen, “The effects of vitamins E and C on fracture healing in rats,” Journal of International Medical Research, vol. 30, no. 3, pp. 309–313, 2002.
- O. O. Oni, J. Dunning, R. J. Mobbs, and P. J. Gregg, “Clinical factors and the size of the external callus in tibial shaft fractures,” Clinical Orthopaedics and Related Research, no. 273, pp. 278–283, 1991.
- C. Kilkenny, W. J. Browne, I. C. Cuthill, M. Emerson, and D. G. Altman, “Improving bioscience research reporting: the arrive guidelines for reporting animal research,” PLoS Biology, vol. 8, no. 6, Article ID e1000412, 2010.
- B. Prajapati, M. Dunne, and R. Armstrong, “Sample size estimation and statistical power analyses,” Optometry Today, 2010.
- G. T. Sica, “Bias in research studies,” Radiology, vol. 238, no. 3, pp. 780–789, 2006.
- P. Araujo and L. Frøyland, “Statistical power and analytical quantification,” Journal of Chromatography B, vol. 847, no. 2, pp. 305–308, 2007.
- J. Cohen, Statistical Power Analysis for the Behavioral Sciences, Lawrence Erlbaum, NJ, USA, 1988.
- P. Cronin, F. Ryan, and M. Coughlan, “Undertaking a literature review: a step-by-step approach,” British Journal of Nursing, vol. 17, no. 1, pp. 38–43, 2008.
- L. Claes, S. Recknagel, and A. Ignatius, “Fracture healing under healthy and inflammatory conditions,” Nature Reviews Rheumatology, vol. 8, no. 3, pp. 133–143, 2012.
- K. Durak, O. F. Bilgen, T. Kaleli, P. Tuncel, R. Ozbek, and K. Turan, “Antioxidant effect of α-tocopherol on fracture haematoma in rabbits,” Journal of International Medical Research, vol. 24, no. 5, pp. 419–424, 1996.
- N. S. Young, J. P. A. Ioannidis, and O. Al-Ubaydli, “Why current publication practices may distort science,” PLoS Medicine, vol. 5, no. 10, article no. e201, pp. 1418–1422, 2008.
- B. Phillips, C. Ball, S. Sackett et al., “Levels of evidence (March 2009),” 2009, http://www.cebm.net/index.aspx?o=1025.
- M. Turlik, “Introduction to evidence based medicine,” The Foot & Ankle Journal, vol. 2, no. 2, 2009.
- P. Pound, S. Ebrahim, P. Sandercock, M. B. Bracken, and I. Roberts, “Where is the evidence that animal research benefits humans?” British Medical Journal, vol. 328, no. 7438, pp. 514–517, 2004.
- V. Bebarta, D. Luyten, and K. Heard, “Emergency medicine animal research: does use of randomization and blinding affect the results?” Academic Emergency Medicine, vol. 10, no. 6, pp. 684–687, 2003.
- M. F. W. Festing and D. G. Altman, “Guidelines for the design and statistical analysis of experiments using laboratory animals,” ILAR Journal, vol. 43, no. 4, pp. 244–257, 2002.
- C. G. Begley and L. M. Ellis, “Raise standards for preclinical cancer research,” Nature, vol. 483, no. 7391, pp. 531–533, 2012.
- A. R. E. N. A. Office of Laboratory Animal Welfare, Institutional Animal Care and Use Committee Guidebook, Office of Laboratory Animal Welfare, Bethesda, MD, USA, 2nd edition, 2002.
- W. M. S. Russell and R. L. Burch, The Principles of Humane Experimental Techniques, Methuen & Co, London, 1959.
- R. M. Baron and D. A. Kenny, “The moderator-mediator variable distinction in social psychological research. conceptual, strategic, and statistical considerations,” Journal of Personality and Social Psychology, vol. 51, no. 6, pp. 1173–1182, 1986.
- P. A. Frazier, A. P. Tix, and K. E. Barron, “Testing moderator and mediator effects in counseling psychology research,” Journal of Counseling Psychology, vol. 51, no. 1, pp. 115–134, 2004.
- C. M. Lockwood, C. A. DeFrancesco, D. L. Elliot, S. A. A. Beresford, and D. J. Toobert, “Mediation analyses: applications in nutrition research and reading the literature,” Journal of the American Dietetic Association, vol. 110, no. 5, pp. 753–762, 2010.
- R. Armstrong, N. Jackson, J. Doyle, E. Waters, and F. Howes, “It's in your hands: the value of handsearching in conducting systematic reviews of public health interventions,” Journal of Public Health, vol. 27, no. 4, pp. 388–391, 2005.