Traditional Chinese Medicine for Senile Dementia

Table 3

Memory-improving and neuro-protective effects of Poria cocos.

Test	Test materials/dose	Test model	Endpoints/biomarkers	Effects	Reference
In vivo	Extracts 20–100 mg/kg	Scopolamine-treated rats	Eight-arm radial maze	Improve spatial memory	[20]
	Extracts 250–500 mg/kg	Innate rats	Electro-physiology Spike amplitude	Enhance hippocampal LTP	[21]
	Methanol extracts 200 mg/mL	Ellman ChE	ChE activity	Inhibit ChE by 27.8%	[22]
	Aqueous extracts 0.2 mg/mL	Innate ICR mice	AChE activity	Inhibit AChE by 13.9%	[23]
In vitro	Aqueous extracts 31–250 μg/mL	Brain neurons–neonatal rats	Cytosolic [Ca^2+] i	Regulate bi-directly [Ca^2+] i	[24]

Long-term potentiation (LTP); choline esterase (ChE); acetylcholinesterase (AChE).