Research Article

Acute and Chronic Administrations of Rheum palmatum Reduced the Bioavailability of Phenytoin in Rats: A New Herb-Drug Interaction

Figure 4

Effects of indomethacin (Indo) on the intracellular accumulation of PHT ((a), 10 μM) and HPPH ((b), 10 μM) in MDCKII and MDCKII-MRP 2 cells. Data expressed as mean ± S.D. of four determinations. * .
701205.fig.004a
(a)
701205.fig.004b
(b)