Acute and Chronic Administrations of Rheum palmatum Reduced the Bioavailability of Phenytoin in Rats: A New Herb-Drug Interaction
Figure 5
Effects of RP metabolites (RPMs) and indomethacin (Indo, 200 μM as a positive control of MRP 2 inhibitor) on the accumulation of PHT (a) and HPPH (b) in MDCKII-MRP2 cells. Data expressed as mean ± S.D. of five determinations. *. RPMs-I, II, III: 1.0-, 0.5-, and 0.25-fold serum concentration, respectively (1.0-fold: containing 2.3 μM of aloe emodin G/S, 6.4 μM of rhein, 13.0 μM of rhein G/S, 4.1 μM of emodin G/S, and 2.0 μM of chrysophanol G/S).
