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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 716459, 7 pages
http://dx.doi.org/10.1155/2012/716459
Review Article

Tanshinone IIA: A Promising Natural Cardioprotective Agent

1Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China
2National Integrative Medicine Center for Cardiovascular Diseases, China-Japan Friendship Hospital, Beijing 100029, China
3Cardiovascular Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China

Received 7 October 2011; Accepted 3 November 2011

Academic Editor: Keji Chen

Copyright © 2012 Qinghua Shang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Tanshinone IIA (Tan IIA) is a member of the major lipophilic components extracted from the root of Salvia miltiorrhiza Bunge, which is currently used in China and other neighboring countries to treat patients suffering from myocardial infarction (MI), angina pectoris, stroke, diabetes, sepsis, and other conditions. However, Tan IIA is not easy to be absorbed through intestinal pathway. To raise the bioavailability of the herb, sodium tanshinone IIA sulfonate (STS) was developed. This paper discussed the pharmacology of Tan IIA, STS, and their potential cardioprotective effects.