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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 717123, 6 pages
http://dx.doi.org/10.1155/2012/717123
Research Article

Cardioprotective Effect of the Compound Yangshen Granule in Rat Models with Acute Myocardial Infarction

1Formulary Department, Beijing University of Chinese Medicine, Beijing 100029, China
2Pharmacology Department, Anhui College of Chinese Medicine, Hefei, Anhui 230000, China

Received 10 October 2011; Revised 28 December 2011; Accepted 10 January 2012

Academic Editor: Hao Xu

Copyright © 2012 Xie Ming et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The protective effect of Compound Yangshen Granules was observed in myocardial infarction rat model. Rats were randomly divided into 6 groups: the model group, the control group (sham operated), the positive drug group, and small, medium, and large dosage of the Yangshen granule groups, respectively. The rats in the 3 Yangshen granule groups were orally administrated with 0.7 g/kg, 1.4 g/kg, and 2.8 g/kg for 7 consecutive days, whereas the rats of the positive drug group treated with 0.14 g/kg of Danshen Dropping Pills, and rats in the control and model groups orally administrated with saline. The rat model of acute myocardial infarction was established with ligation of coronary artery. Electrocardiograms at different time points, the blood rheology, myocardial enzymes, infarct size, and myocardial morphologic changes were measured. The results demonstrated that the granules could improve blood rheology, decrease st-segment of electrocardiograms and the activities of LDH and CK in serum, reduce myocardial infarction size, and alleviate myocardial histopathologic changes. In addition, the effect of the granules depended on the dose administrated orally. The results suggest that the Yangshen granules could produce cardioprotection effect and have potential benefits in the prevention of ischemic heart disease.