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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 726025, 15 pages
Research Article

Shikonin Directly Targets Mitochondria and Causes Mitochondrial Dysfunction in Cancer Cells

1Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany
2Cytometry Core Facility, Institute of Molecular Biology, Ackermannweg 4, 55128 Mainz, Germany

Received 10 July 2012; Accepted 7 September 2012

Academic Editor: Ke Liu

Copyright © 2012 Benjamin Wiench et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [6 citations]

The following is the list of published articles that have cited the current article.

  • Heyong Wang, Chunlian Wu, Shengbang Wan, Huijun Zhang, Songwen Zhou, and Gentao Liu, “Shikonin attenuates lung cancer cell adhesion to extracellular matrix and metastasis by inhibiting integrin β1 expression and the ERK1/2 signaling pathway,” Toxicology, vol. 308, pp. 104–112, 2013. View at Publisher · View at Google Scholar
  • Benjamin Wiench, Yet-Ran Chen, Malte Paulsen, Rebecca Hamm, Sven Schröder, Ning-Sun Yang, and Thomas Efferth, “Integration of Different “-omics” Technologies Identifies Inhibition of the IGF1R-Akt-mTOR Signaling Cascade Involved in the Cytotoxic Effect of Shikonin against Leukemia Cells,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, pp. 1–11, 2013. View at Publisher · View at Google Scholar
  • I. Andujar, M. C. Recio, and R. M. Giner, “Traditional Chinese Medicine Remedy to Jury: The Pharmacological Basis for the Use of Shikonin as an Anticancer Therapy,” Current Medicinal Chemistry, vol. 20, no. 23, pp. 2892–2898, 2013. View at Publisher · View at Google Scholar
  • Sun-Joong Kim, Jee Min Kim, So Hee Shim, and Hyo Ihl Chang, “Shikonin induces cell cycle arrest in human gastric cancer (AGS) by early growth response 1 (Egr1)-mediated p21 gene expression,” Journal of Ethnopharmacology, vol. 151, no. 3, pp. 1064–1071, 2014. View at Publisher · View at Google Scholar
  • Yoshikatsu Ogawa, Yasuhiro Kawano, and Yoshimitsu Yamazaki, “Shikonin shortens the circadian period: Possible involvement of Top2 inhibi tion,” Biochemical and Biophysical Research Communications, vol. 443, no. 1, pp. 339–343, 2014. View at Publisher · View at Google Scholar
  • Efthymia-Iliana Matthaiou, Jaleh Barar, Raphael Sandaltzopoulos, Chunsheng Li, and Yadollah Omidi, “Shikonin-loaded antibody-armed nanoparticles for targeted therapy of ovaria n cancer,” International Journal of Nanomedicine, vol. 9, pp. 1855–1870, 2014. View at Publisher · View at Google Scholar