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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 726025, 15 pages
http://dx.doi.org/10.1155/2012/726025
Research Article

Shikonin Directly Targets Mitochondria and Causes Mitochondrial Dysfunction in Cancer Cells

1Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany
2Cytometry Core Facility, Institute of Molecular Biology, Ackermannweg 4, 55128 Mainz, Germany

Received 10 July 2012; Accepted 7 September 2012

Academic Editor: Ke Liu

Copyright © 2012 Benjamin Wiench et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The Supplementary Material contains a comparison of the results of the microarray gene expression and the real-time reverse transcription PCR for six selected genes (Table S1). Shikonin-affected mechanisms in U937 cells detected by gene expression analysis are summarized in Figure S1. Furthermore video recordings showing the effect of shikonin on the microtubule cytoskeleton are provided (Video S1 and Video S2).

  1. Supplementary Material
  2. Supplementary Video 1
  3. Supplementary Video 2