A Therapeutic Approach for Wound Healing by Using Essential Oils of Cupressus and Juniperus Species Growing in Turkey

Table 5

Wound healing processes and healing phases of the vehicle, negative control, test ointments, and Madecassol-administered animals.

Groups	Wound healing processes
Vehicle	S	U	RE	FP	CD	MNC	PMN	NV
Negative control	++/+++	+++	—	++/+++	++	+++	++/+++	++
C. sempervirens var. horizontalis	++/+++	++/+++	—	++/+++	++	++	++/+++	++/+++
C. sempervirens var. pyramidalis	++	++/+++	—	++	++	+/++	++	++
J. communis subsp. nana Syme.	++/+++	++/+++	—	++/+++	++	+/++	++	+++
J. excelsa	++/+++	++/+++	—	++	+/++	++	++	+/++
J. foetidissima	+/++	+/++	−/+	++	+/++	+/++	+/++	++
J. oxycedrus subsp. oxycedrus	++	+/++	−/+	++	+/++	+/++	+/++	+/++
J. phoenicea	+/++	+/++	−/+	++	+/++	+/++	+/++	++
Madecassol	+/++	−/+	+	++	+/++	+	+/++	+/++

HE- and VG-stained sections were scored as mild (+), moderate (++), and severe (+++) for epidermal and/or dermal remodeling. S: scab, U: ulcer, RE: re-epithelization, FP: fibroblast proliferation, CD: collagen depositions, MNC: mononuclear cells, PMN: polymorphonuclear cells, NV: neovascularization, I: inflammation phase, P: proliferation phase, and R: remodeling phase.