Portulaca oleracea Ameliorates Diabetic Vascular Inflammation and Endothelial Dysfunction in db/db Mice

Figure 6

Effect of AP on VCAM-1 and ET-1 immunoreactivity in the aorta of db/db mice. (A) Immunohistochemical staining of VCAM-1 or ET-1 in aorta from (a, e) WT, (b, f) untreated db/db mice, (e, g) db/db mice treated with rosiglitazone (10 mg/kg/day), and (d, h) db/db mice treated with AP (300 mg/kg/day). Lower panels show quantitative analysis of VCAM-1- (B) and ET-1- (C) -positive area. The average score of 5–10 randomly selected sites per section of aorta was calculated. Data expressed as mean ± SE; ^∗∗𝑃<0.01 versus WT; ^##𝑃<0.01 versus db/db control. Original magnification:1000x.