Inhibitory Effect of Curcumol on Jak2-STAT Signal Pathway Molecules of Fibroblast-Like Synoviocytes in Patients with Rheumatoid Arthritis

Table 1

Effect of different concentrations of curcumol on STAT1 and STAT3 activities in FLS from patients with RA.

Groups	STAT DNA-binding activities
	STAT1	STAT3
Lane 2 (normal control)	168.75±58.54	176.50 ± 25.51
Lane 3 (PDGF-BB 25 ng/mL)	296.75±72.96^#	344.50±50.98^#
Lane 4 (curcumol 25 μg/mL)	90.65±14.94 *	116.38±17.81 **
Lane 5 (curcumol 50 μg/mL)	109.13±11.86 *	96.38±23.24 **
Lane 6 (curcumol 100 μg/mL)	87.38±13.24 *	81.38±15.56 **

Each value represents the mean ± S.D. for three independent experiments. *𝑃<0.05 versus PDGF-BB. **𝑃<0.01 versus PDGF-BB (Dunnett’s 𝑡-test). ^#𝑃<0.05 versus normal control (Student’s 𝑡-test); one-way ANOVA revealed significant effects between PDGF-BB and drug treatment groups (𝐹=27.823, 𝑃=0.000 for STAT1, 𝐹=66.587, 𝑃=0.000 for STAT3).