Research Article

Inhibitory Effect of Curcumol on Jak2-STAT Signal Pathway Molecules of Fibroblast-Like Synoviocytes in Patients with Rheumatoid Arthritis

Table 2

Effect of different concentrations of curcumol on p-Jak2, STAT1, and STAT3 in FLS from patients with RA.

GroupsNormalized density (target protein/β-actin)
p-Jak2STAT1STAT3

Lane 1 (normal control)
Lane 2 (PDGF-BB 25 ng/mL) ## #
Lane 3 (curcumol 25 μg/mL)
Lane 4 (curcumol 50 μg/mL) **

Each value represents the mean ± S.D. for three independent experiments. * versus PDGF-BB. ** versus PDGF-BB (Dunnett’s -test). # versus normal control. ## versus normal control (Student’s -test); one-way ANOVA revealed insignificant effects between PDGF-BB and drug treatment groups ( , for STAT1, , for STAT3).