Evidence-Based Complementary and Alternative Medicine

Research Article

Antimicrobial Activity of Essential Oils against Streptococcus mutans and their Antiproliferative Effects

Table 4

Total growth inhibition (TGI) of selected essential oils and their selected active fractions tested against normal human cell and tumor cell lines.


Cell line		TGI (μg/mL)¹
	Ag EO	Ag₄	Bd EO	Bd₂	Cs EO	Cs₄	Ls EO	Ls₃	Dox

Glioma (U251)	>250	55.6	38.2	51.4	8.3	61.5	>250	94.9	0.92
Breast (MCF-7)	>250	45.2	46.0	67.7	13.6	111.6	>250	56.6	3.3
Ovarian (NCI-ADR/RES)	>250	50.6	59.2	10.5	90.0	13.1	>250	112.3	1.6
Kidney (786-0)	>250	5.9	49.5	47.1	29.8	72.1	>250	26.7	>250
Lung (NCI-H460)	>250	42.7	87.6	76.8	105.0	110.3	>250	79.8	4.9
Prostate (PC-3)	99.9	>250	>250	>250	118.1	141.9	26.7	>250	11.7
Ovarian (OVCAR-3)	<0.25	47.6	<0.25	58.0	<0.25	73.7	<0.25	60.4	7.6
Keratinocytes (HaCaT)	>250	>250	92.3	95.7	129.4	145.6	>250	>250	2.3

¹Data result from three replicates per treatment in two independent tests at 25°C for 48 hours. Ag EO, Bd EO, Cs EO, and Ls EO correspond to the following essential oils: Aloysia gratissima, Baccharis dracunculifolia, Coriandrum sativum, and Lippia sidoides, respectively. Ag₄, Bd₂, Cs₄, and Ls₃ are the selected active fractions evaluated. Dox: doxorubicin (positive control).