Effects of Rhizophora mangle on Experimental Colitis Induced by TNBS in Rats

Table 5

Effect of BuOH fraction and EtOAc fraction on colonic TNF-α, IL-6, IL12, and IL-10 levels in TNBS-induced colitis in rats.

Group	Colon TNF-α levels; (pg/mg of protein)	Colon IL-6 levels; (pg/mg of protein)	Colon IL-12 levels; (pg/mg of protein)	Colon IL-10 levels; (pg/mg of protein)
Noncolitic	357.3 ± 20.7***	209.1 ± 24.3***	12.7 ± 1.9***	295.0 ± 37.7***
Colitic nontreated	1381.0 ± 227.5	807.3 ± 45.5	28.5 ± 2.4	120.4 ± 4.3
BuOH fraction 0.5 mg/Kg	469.5 ± 21.5***	719.1 ± 17.4	16.72 ± 1.0***	152.5 ± 11.6
EtOAc fraction 1.5 mg/Kg	567.9 ± 21.8***	615.4 ± 54.4**	19.09 ± 1.7**	252.1 ± 19.3**

Results are presented as mean ± SEM ANOVA followed by Dunnett’s t-test, *𝑃<0.05, **𝑃<0.01, ***𝑃<0.001 significantly different from colitic nontreated.