- About this Journal
- Abstracting and Indexing
- Aims and Scope
- Annual Issues
- Article Processing Charges
- Articles in Press
- Author Guidelines
- Bibliographic Information
- Citations to this Journal
- Contact Information
- Editorial Board
- Editorial Workflow
- Free eTOC Alerts
- Publication Ethics
- Reviewers Acknowledgment
- Submit a Manuscript
- Subscription Information
- Table of Contents
Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 758097, 10 pages
Flavonoid Myricetin Modulates Receptor Activity through Activation of Channels and CaMK-II Pathway
1Epithelial Cell Biology Research Centre, The Chinese University of Hong Kong, Hong Kong
2Department of Physiology, Medical College Qingdao University, Qingdao, China
3Laboratory Animal Services Centre, The Chinese University of Hong Kong, Hong Kong
4Department of Physiology, School of Basic Medical Sciences, Jilin University, Changchun, China
5School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
Received 20 June 2012; Revised 31 July 2012; Accepted 10 August 2012
Academic Editor: Ke Ren
Copyright © 2012 Xiao Hu Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- M. Watanabe, K. Maemura, K. Kanbara, T. Tamayama, and H. Hayasaki, “GABA and GABA receptors in the central nervous system and other organs,” in International Review of Cytology A Survey of Cell Biology. Volume 213, W. J. Kwang, Ed., pp. 1–47, Academic Press, New York, NY, USA, 2002.
- C. Gottesmann, “GABA mechanisms and sleep,” Neuroscience, vol. 111, no. 2, pp. 231–239, 2002.
- H. Möhler, “ receptor diversity and pharmacology,” Cell and Tissue Research, vol. 326, no. 2, pp. 505–516, 2006.
- E. Szabadi, “Drugs for sleep disorders: mechanisms and therapeutic prospects,” British Journal of Clinical Pharmacology, vol. 61, no. 6, pp. 761–766, 2006.
- B. E. Jones, “From waking to sleeping: neuronal and chemical substrates,” Trends in Pharmacological Sciences, vol. 26, no. 11, pp. 578–586, 2005.
- R. W. McCarley, “Neurobiology of REM and NREM sleep,” Sleep Medicine, vol. 8, no. 4, pp. 302–330, 2007.
- S. M. Richey and A. D. Krystal, “Pharmacological advances in the treatment of insomnia,” Current Pharmaceutical Design, vol. 17, no. 15, pp. 1471–1475, 2011.
- S. Saddichha, “Diagnosis and treatment of chronic insomnia,” Annals of Indian Academy of Neurology, vol. 13, no. 2, pp. 94–102, 2010.
- J. Seibt, S. J. Aton, S. K. Jha, T. Coleman, M. C. Dumoulin, and M. G. Frank, “The non-benzodiazepine hypnotic zolpidem impairs sleep-dependent cortical plasticity,” Sleep, vol. 31, no. 10, pp. 1381–1391, 2008.
- G. Hajak, W. E. Müller, H. U. Wittchen, D. Pittrow, and W. Kirch, “Abuse and dependence potential for the non-benzodiazepine hypnotics zolpidem and zopiclone: a review of case reports and epidemiological data,” Addiction, vol. 98, no. 10, pp. 1371–1378, 2003.
- J. B. Harborne and C. A. Williams, “Advances in flavonoid research since 1992,” Phytochemistry, vol. 55, no. 6, pp. 481–504, 2000.
- F. Wang, M. S. Y. Huen, S. Y. Tsang, and H. Xue, “Neuroactive flavonoids interacting with receptor complex,” Current Drug Targets, vol. 4, no. 5, pp. 575–585, 2005.
- G. Griebel, G. Perrault, S. Tan, H. Schoemaker, and D. J. Sanger, “Pharmacological studies on synthetic flavonoids: comparison with diazepam,” Neuropharmacology, vol. 38, no. 7, pp. 965–977, 1999.
- K. C. Ong and H. E. Khoo, “Biological effects of myricetin,” General Pharmacology, vol. 29, no. 2, pp. 121–126, 1997.
- I. M. Liu, T. F. Tzeng, S. S. Liou, and T. W. Lan, “Improvement of insulin sensitivity in obese Zucker rats by myricetin extracted from Abelmoschus moschatus,” Planta Medica, vol. 73, no. 10, pp. 1054–1060, 2007.
- P. Nirmala and M. Ramanathan, “Effect of myricetin on 1,2 dimethylhydrazine induced rat colon carcinogenesis,” Journal of Experimental Therapeutics and Oncology, vol. 9, no. 2, pp. 101–108, 2011.
- Z. G. Ma, J. Wang, H. Jiang, T. W. Liu, and J. X. Xie, “Myricetin reduces 6-hydroxydopamine-induced dopamine neuron degeneration in rats,” NeuroReport, vol. 18, no. 11, pp. 1181–1185, 2007.
- D. Schwarz, P. Kisselev, W. H. Schunck, and I. Roots, “Inhibition of 17β-estradiol activation by CYP1A1: genotype- and regioselective inhibition by St. John's Wort and several natural polyphenols,” Biochimica et Biophysica Acta, vol. 1814, no. 1, pp. 168–174, 2011.
- F. C. Meotti, A. P. Luiz, M. G. Pizzolatti, C. A. L. Kassuya, J. B. Calixto, and A. R. S. Santos, “Analysis of the antinociceptive effect of the flavonoid myricitrin: evidence for a role of the L-arginine-nitric oxide and protein kinase C pathways,” Journal of Pharmacology and Experimental Therapeutics, vol. 316, no. 2, pp. 789–796, 2006.
- F. C. Meotti, R. Fachinetto, L. C. Maffi et al., “Antinociceptive action of myricitrin: Involvement of the K+ and Ca2+ channels,” European Journal of Pharmacology, vol. 567, no. 3, pp. 198–205, 2007.
- T. Hagenacker, I. Hillebrand, A. Wissmann, D. Büsselberg, and M. Schäfers, “Anti-allodynic effect of the flavonoid myricetin in a rat model of neuropathic pain: involvement of p38 and protein kinase C mediated modulation of Ca2+ channels,” European Journal of Pain, vol. 14, no. 10, pp. 992–998, 2010.
- E. Mignot, S. Taheri, and S. Nishino, “Sleeping with the hypothalamus: emerging therapeutic targets for sleep disorders,” Nature Neuroscience, vol. 5, pp. 1071–1075, 2002.
- R. Szymusiak, I. Gvilia, and D. McGinty, “Hypothalamic control of sleep,” Sleep Medicine, vol. 8, no. 4, pp. 291–301, 2007.
- C. B. Saper, T. E. Scammell, and J. Lu, “Hypothalamic regulation of sleep and circadian rhythms,” Nature, vol. 437, no. 7063, pp. 1257–1263, 2005.
- J. P. Herman, J. G. Tasker, D. R. Ziegler, and W. E. Cullinan, “Local circuit regulation of paraventricular nucleus stress integration: glutamate-GABA connections,” Pharmacology Biochemistry and Behavior, vol. 71, no. 3, pp. 457–468, 2002.
- R. Winsky-Sommerer, A. Yamanaka, S. Diano et al., “Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response,” Journal of Neuroscience, vol. 24, no. 50, pp. 11439–11448, 2004.
- R. Winsky-Sommerer, B. Boutrel, and L. de Lecea, “Stress and arousal: the corticotrophin-releasing factor/hypocretin circuitry,” Molecular Neurobiology, vol. 32, no. 3, pp. 285–294, 2005.
- A. N. Vgontzas and G. P. Chrousos, “Sleep, the hypothalamic-pituitary-adrenal axis, and cytokines: multiple interactions and disturbances in sleep disorders,” Endocrinology and Metabolism Clinics of North America, vol. 31, no. 1, pp. 15–36, 2002.
- R. S. Vijayan, D. Bhattacharyya, and N. Ghoshal, “Deciphering the binding mode of Zolpidem to GABA(A) alpha (1) receptor—insights from molecular dynamics simulation,” Journal of Molecular Modeling, vol. 18, no. 4, pp. 1345–1354, 2012.
- L. Chen, C. S. Chan, and W. H. Yung, “Electrophysiological and behavioral effects of zolpidem in rat globus pallidus,” Experimental Neurology, vol. 186, no. 2, pp. 212–220, 2004.
- B. J. Mcdonald and S. J. Moss, “Conserved phosphorylation of the intracellular domains of GABA(A) receptor β2 and β3 subunits by cAMP-dependent protein kinase, cGMP-dependent protein kinase, protein kinase C and Ca2+/calmodulin type II-dependent protein kinase,” Neuropharmacology, vol. 36, no. 10, pp. 1377–1385, 1997.
- K. C. Marsden, A. Shemesh, K. U. Bayer, and R. C. Carroll, “Selective translocation of Ca2+/calmodulin protein kinase IIα (CaMKIIα) to inhibitory synapses,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 47, pp. 20559–20564, 2010.
- C. M. Houston, Q. He, and T. G. Smart, “CaMKII phosphorylation of the receptor: receptor subtype- and synapse-specific modulation,” Journal of Physiology, vol. 587, no. 10, pp. 2115–2125, 2009.
- C. M. Houston, H. H. C. Lee, A. M. Hosie, S. J. Moss, and T. G. Smart, “Identification of the sites for CaMK-II-dependent phosphorylation of receptors,” Journal of Biological Chemistry, vol. 282, no. 24, pp. 17855–17865, 2007.
- H. Tokumitsu, T. Chijiwa, M. Hagiwara, A. Mizutani, M. Terasawa, and H. Hidaka, “KN-62, 1-[N,O-Bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperaz ine, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II,” Journal of Biological Chemistry, vol. 265, no. 8, pp. 4315–4320, 1990.
- M. Kano, M. Kano, K. Fukunaga, and A. Konnerth, “Ca2+-induced rebound potentiation of γ-aminobutyric acid-mediated currents requires activation of Ca2+/calmodulin-dependent kinase II,” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 23, pp. 13351–13356, 1996.
- Y. Mizoguchi, H. Ishibashi, and J. Nabekura, “The action of BDNF on currents changes from potentiating to suppressing during maturation of rat hippocampal CA1 pyramidal neurons,” Journal of Physiology, vol. 548, no. 3, pp. 703–709, 2003.
- F. Fusi, S. Saponara, M. Frosini, B. Gorelli, and G. Sgaragli, “L-type Ca2+ channels activation and contraction elicited by myricetin on vascular smooth muscles,” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 368, no. 6, pp. 470–478, 2003.
- F. Fusi, G. Sgaragli, and S. Saponara, “Mechanism of myricetin stimulation of vascular L-type Ca2+ current,” Journal of Pharmacology and Experimental Therapeutics, vol. 313, no. 2, pp. 790–797, 2005.
- K. A. Skelding and J. A. P. Rostas, “Regulation of CaMKII in vivo: the importance of targeting and the intracellular microenvironment,” Neurochemical Research, vol. 34, no. 10, pp. 1792–1804, 2009.
- G. Gandolfo, R. Scherschlicht, and C. Gottesmann, “Benzodiazepines promote the intermediate stage at the expense of paradoxical sleep in the rat,” Pharmacology Biochemistry and Behavior, vol. 49, no. 4, pp. 921–927, 1994.
- I. Tobler, C. Kopp, T. Deboer, and U. Rudolph, “Diazepam-induced changes in sleep: role of the α1 receptor subtype,” Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 11, pp. 6464–6469, 2001.
- P. Halász, M. Terzano, L. Parrino, and R. Bódizs, “The nature of arousal in sleep,” Journal of Sleep Research, vol. 13, no. 1, pp. 1–23, 2004.
- M. P. Anderson, T. Mochizuki, J. Xie et al., “Thalamic Cav3.1 T-type Ca2+ channel plays a crucial role in stabilizing sleep,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 5, pp. 1743–1748, 2005.
- V. Crunelli, D. W. Cope, and S. W. Hughes, “Thalamic T-type Ca2+ channels and NREM sleep,” Cell Calcium, vol. 40, no. 2, pp. 175–190, 2006.
- K. A. Wafford and B. Ebert, “Emerging anti-insomnia drugs: tackling sleeplessness and the quality of wake time,” Nature Reviews Drug Discovery, vol. 7, no. 6, pp. 530–540, 2008.