Antirheumatoid Arthritis Activities and Chemical Compositions of Phenolic Compounds-Rich Fraction from Urtica atrichocaulis, an Endemic Plant to China
Table 6
The antirheumatoid arthritis activities of the main phenolic compounds and their combination.
Group
Dose (mg/kg)
Paw swell (mm)
Arthritis index
12 d
16 d
20 d
12 d
16 d
20 d
R
L
R
L
R
L
Vehicle
—
4.45 ± 0.93
3.80 ± 0.61
4.16 ± 0.89
4.03 ± 0.77
3.89 ± 0.54
3.57 ± 0.61
8.5 ± 2.3
10.8 ± 1.7
11.1 ± 2.4
Dexamethasone
30
3.33 ± 0.65*
3.09 ± 0.87*
2.92 ± 0.72**
2.84 ± 0.47**
2.23 ± 0.42**
2.24 ± 0.58**
6.2 ± 1.7*
4.9 ± 1.8**
3.7 ± 2.7**
Salicylic acid
50
3.57 ± 0.89*
3.67 ± 0.79
3.34 ± 0.56*
3.51 ± 0.83
2.95 ± 0.61*
3.25 ± 0.43
7.7 ± 2.8
10.1 ± 2.5
9.8 ± 1.7
Phaselic acid
50
3.88 ± 0.89
3.52 ± 0.85
3.09 ± 0.67**
3.62 ± 0.53
2.71 ± 0.49**
3.28 ± 0.73
6.9 ± 2.6
9.8 ± 1.7
10.4 ± 2.1
Chlorogenic acid
50
4.21 ± 0.66
3.55 ± 0.44
3.73 ± 0.75
3.66 ± 0.59
3.56 ± 0.85
3.39 ± 0.76
8.1 ± 2.5
10.3 ± 1.7
10.8 ± 2.3
Rutin
50
4.36 ± 0.80
3.40 ± 0.67
3.92 ± 0.54
3.29 ± 0.47*
3.78 ± 0.92
2.83 ± 0.87*
7.6 ± 2.0
9.3 ± 1.3
8.7 ± 1.9*
Combinationa
50
3.48 ± 0.72*
3.21 ± 0.58*
3.40 ± 0.71*
3.04 ± 0.55**
2.84 ± 0.65**
2.61 ± 0.77**
7.2 ± 1.8
9.0 ± 1.9*
8.2 ± 1.5*
Values are expressed as mean ± SD. N = 10. *P < 0.05, **P < 0.01 compared with vehicle control. aThe ratio of rutin : chlorogenic acid : phaselic acid : salicylic acid in combination was 12 : 9 : 6 : 5, according to their contents in phenolic compounds-rich fraction from Urtica atrichocaulis (TFUA).
