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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 820415, 13 pages
Dietary Crocin Inhibits Colitis and Colitis-Associated Colorectal Carcinogenesis in Male ICR Mice
1Division of Palliative Care and Department of Internal Medicine, Tokai Central Hospital, 4-6-2 Sohara-Higashijima-cho, Kakamigahara 504-8601, Japan
2Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis Ten Bosch-cho, Sasebo 859-3298, Japan
3Department of Pathology, Murakami Memorial Hospital, Asahi University, 3-23 Hashimoto-cho, Gifu 500-8523, Japan
4Department of Pharmacy, Ogaki Municipal Hospital, 4-86 Minaminokawa-cho, Ogaki 503-8502, Japan
5Division of Cytopathology, The Tokai Cytopathology Institute: Cancer Research and Prevention (TCI-CaRP), 5-1-2 Minami-Uzura, Gifu 500-8285, Japan
6Department of Tumor Pathology, Graduate School of Medicine, Gifu University, Gifu 501-1194, Japan
Received 5 November 2012; Revised 4 December 2012; Accepted 6 December 2012
Academic Editor: Chong-Zhi Wang
Copyright © 2012 Kunihiro Kawabata et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- F. I. Abdullaev and J. J. Espinosa-Aguirre, “Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials,” Cancer Detection and Prevention, vol. 28, no. 6, pp. 426–432, 2004.
- F. I. Abdullaev, “Cancer chemopreventive and tumoricidal properties of saffron (Crocus sativus L.),” Experimental Biology and Medicine, vol. 227, no. 1, pp. 20–25, 2002.
- M. Giaccio, “Crocetin from saffron: an active component of an ancient spice,” Critical Reviews in Food Science and Nutrition, vol. 44, no. 3, pp. 155–172, 2004.
- W. G. Gutheil, G. Reed, A. Ray, S. Anant, and A. Dhar, “Crocetin: an agent derived from saffron for prevention and therapy for cancer,” Current Pharmaceutical Biotechnology, vol. 13, pp. 173–179, 2012.
- M. A. Papandreou, M. Tsachaki, S. Efthimiopoulos, P. Cordopatis, F. N. Lamari, and M. Margarity, “Memory enhancing effects of saffron in aged mice are correlated with antioxidant protection,” Behavioural Brain Research, vol. 219, no. 2, pp. 197–204, 2011.
- M. Sugiura, Y. Shoyama, H. Saito, and N. Nishiyama, “Crocin improves the ethanol-induced impairment of learning behabiors of mice in passive avoidance tasks,” Proceedings of the Japan Academy B, vol. 71, no. 10, pp. 319–324, 1995.
- H. Hosseinzadeh and F. Talebzadeh, “Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice,” Fitoterapia, vol. 76, no. 7-8, pp. 722–724, 2005.
- S. Akhondzadeh, H. Fallah-Pour, K. Afkham, A. H. Jamshidi, and F. Khalighi-Cigaroudi, “Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: a pilot double-blind randomized trial [ISRCTN45683816],” BMC Complementary and Alternative Medicine, vol. 4, article 12, 2004.
- H. Hosseinzadeh and H. M. Younesi, “Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice,” BMC Pharmacology, vol. 2, article 7, 2002.
- H. A. Kazi and Z. Qian, “Crocetin reduces TNBS-induced experimental colitis in mice by downregulation of NFkB,” Saudi Journal of Gastroenterology, vol. 15, no. 3, pp. 181–187, 2009.
- M. H. Carlsen, B. L. Halvorsen, K. Holte et al., “The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide,” Nutrition Journal, vol. 9, no. 1, article 3, 2010.
- H. A. El-Beshbishy, M. H. Hassan, H. A. Aly, A. S. Doghish, and A. A. Alghaithy, “Crocin ‘saffron’ protects against beryllium chloride toxicity in rats through diminution of oxidative stress and enhancing gene expression of antioxidant enzymes,” Ecotoxicology and Environmental Safety, vol. 83, pp. 47–54, 2012.
- F. Yoshino, A. Yoshida, N. Umigai, K. Kubo, and M. C. Lee, “Crocetin reduces the oxidative stress induced reactive oxygen species in the stroke-prone spontaneously hypertensive rats (SHRSPs) brain,” Journal of Clinical Biochemistry and Nutrition, vol. 49, no. 3, pp. 182–187, 2011.
- H. Bakshi, S. Sam, R. Rozati et al., “DNA fragmentation and cell cycle arrest: a hallmark of apoptosis induced by crocin from Kashmiri Saffron in a human pancreatic cancer cell line,” The Asian Pacific Journal of Cancer Prevention, vol. 11, no. 3, pp. 675–679, 2010.
- R. Yang, K. Vernon, A. Thomas, D. Morrison, N. Qureshi, and C. W. van Way III, “Crocetin reduces activation of hepatic apoptotic pathways and improves survival in experimental hemorrhagic shock,” Journal of Parenteral and Enteral Nutrition, vol. 35, no. 1, pp. 107–113, 2011.
- I. A. Lee, J. H. Lee, N. I. Baek, and D. H. Kim, “Antihyperlipidemic effect of crocin isolated from the fructus of Gardenia jasminoides and its metabolite crocetin,” Biological and Pharmaceutical Bulletin, vol. 28, no. 11, pp. 2106–2110, 2005.
- S. Bani, A. Pandey, V. K. Agnihotri, V. Pathania, and B. Singh, “Selective Th2 upregulation by Crocus sativus: a neutraceutical spice,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 639862, 9 pages, 2011.
- G. D. Geromichalos, F. N. Lamari, M. A. Papandreou et al., “Saffron as a source of novel acetylcholinesterase inhibitors: molecular docking and in vitro enzymatic studies,” Journal of Agricultural and Food Chemistry, vol. 60, no. 24, pp. 6131–6138, 2012.
- M. J. R. Howes and E. Perry, “The role of phytochemicals in the treatment and prevention of dementia,” Drugs and Aging, vol. 28, no. 6, pp. 439–468, 2011.
- B. Lin, “Polyphenols and neuroprotection against ischemia and neurodegeneration,” Mini-Reviews in Medicinal Chemistry, vol. 11, no. 14, pp. 1222–1238, 2011.
- T. Konoshima, M. Takasaki, H. Tokuda et al., “Crocin and crocetin devrivatives inhibit skin tumor promotion in mice,” Phytotherapy Research, vol. 12, no. 6, pp. 400–404, 1998.
- H. H. Aung, C. Z. Wang, M. Ni et al., “Crocin from Crocus sativus possesses significant anti-proliferation effects on human colorectal cancer cells,” Experimental Oncology, vol. 29, no. 3, pp. 175–180, 2007.
- S. K. Noureini and M. Wink, “Antiproliferative effects of crocin in HepG2 cells by telomerase inhibition and hTERT down-regulation,” The Asian Pacific Journal of Cancer Prevention, vol. 13, no. 5, pp. 2305–2309, 2012.
- D. G. Chryssanthi, F. N. Lamari, G. Iatrou, A. Pylara, N. K. Karamanos, and P. Cordopatis, “Inhibition of breast cancer cell proliferation by style constituents of different Crocus species,” Anticancer Research, vol. 27, no. 1, pp. 357–362, 2007.
- H. A. Bakshi, S. Sam, A. Feroz, Z. Ravesh, G. A. Shah, and M. Sharma, “Crocin from Kashmiri saffron (Crocus sativus) induces in vitro and in vivo xenograft growth inhibition of Dalton's lymphoma (DLA) in mice,” The Asian Pacific Journal of Cancer Prevention, vol. 10, no. 5, pp. 887–890, 2009.
- I. Das, R. N. Chakrabarty, and S. Das, “Saffron can prevent chemically induced skin carcinogenesis in Swiss albino mice,” The Asian Pacific Journal of Cancer Prevention, vol. 5, no. 1, pp. 70–76, 2004.
- A. Dhar, S. Mehta, G. Dhar et al., “Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mouse model,” Molecular Cancer Therapeutics, vol. 8, no. 2, pp. 315–323, 2009.
- I. Das, S. Das, and T. Saha, “Saffron suppresses oxidative stress in DMBA-induced skin carcinoma: a histopathological study,” Acta Histochemica, vol. 112, no. 4, pp. 317–327, 2010.
- A. Amin, A. A. Hamza, K. Bajbouj, S. S. Ashraf, and S. Daoud, “Saffron: a potential candidate for a novel anticancer drug against hepatocellular carcinoma,” Hepatology, vol. 54, no. 3, pp. 857–867, 2011.
- M. J. Salomi, S. C. Nair, and K. R. Panikkar, “Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice,” Nutrition and Cancer, vol. 16, no. 1, pp. 67–72, 1991.
- T. Tanaka, “Cancer chemoprevention by natural products (review),” Oncology Reports, vol. 1, no. 6, pp. 1139–1155, 1994.
- T. Tanaka, “Colorectal carcinogenesis: review of human and experimental animal studies,” Journal of Carcinogenesis, vol. 8, article 5, 2009.
- T. Tanaka and R. Suzuki, “Inflammation and cancer,” in Cancer: Disease Progression and Chemoprevention 2007, T. Tanaka, Ed., pp. 27–44, Research Signpost, Kerala, India, 2007.
- S. Kraus and N. Arber, “Inflammation and colorectal cancer,” Current Opinion in Pharmacology, vol. 9, no. 4, pp. 405–410, 2009.
- T. Tanaka, H. Kohno, R. Suzuki, Y. Yamada, S. Sugie, and H. Mori, “A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate,” Cancer Science, vol. 94, no. 11, pp. 965–973, 2003.
- D. W. Rosenberg, C. Giardina, and T. Tanaka, “Mouse models for the study of colon carcinogenesis,” Carcinogenesis, vol. 30, no. 2, pp. 183–196, 2009.
- T. Tanaka, “Development of an inflammation-associated colorectal cancer model and its application for research on carcinogenesis and chemoprevention,” International Journal of Inflammation, vol. 2012, Article ID 658786, 16 pages, 2012.
- T. Tanaka, “Preclinical cancer chemoprevention studies using animal model of inflammation-associated colorectal carcinogenesis,” Cancers, vol. 4, no. 3, pp. 673–700, 2012.
- T. Tanaka, M. Shnimizu, and H. Moriwaki, “Cancer chemoprevention by carotenoids,” Molecules, vol. 17, no. 3, pp. 3202–3242, 2012.
- Y. Yasui, M. Hosokawa, N. Mikami, K. Miyashita, and T. Tanaka, “Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in mice via modulation of the inflammatory cytokines,” Chemico-Biological Interactions, vol. 193, no. 1, pp. 79–87, 2011.
- A. Wullaert, M. C. Bonnet, and M. Pasparakis, “NF-kappaB in the regulation of epithelial homeostasis and inflammation,” Cell Research, vol. 21, pp. 146–158, 2011.
- S. Olivier, P. Robe, and V. Bours, “Can NF-kappaB be a target for novel and efficient anti-cancer agents?” Biochemical Pharmacology, vol. 72, no. 9, pp. 1054–1068, 2006.
- H. L. Pahl, “Activators and target genes of Rel/NF-κB transcription factors,” Oncogene, vol. 18, no. 49, pp. 6853–6866, 1999.
- A. C. Bharti and B. B. Aggarwal, “Chemopreventive agents induce suppression of nuclear factor-kappaB leading to chemosensitization,” Annals of the New York Academy of Sciences, vol. 973, pp. 392–395, 2002.
- Y. Li, C. de Haar, M. P. Peppelenbosch, and C. J. van der Woude, “SOCS3 in immune regulation of inflammatory bowel disease and inflammatory bowel disease-related cancer,” Cytokine & Growth Factor Reviews, vol. 23, no. 3, pp. 127–138, 2012.
- E. Talero, S. Sánchez-Fidalgo, I. Villegas, C. A. de la Lastra, M. Illanes, and V. Motilva, “Role of different inflammatory and tumor biomarkers in the development of ulcerative colitis-associated carcinogenesis,” Inflammatory Bowel Diseases, vol. 17, no. 3, pp. 696–710, 2011.
- T. W. Kensler and N. Wakabayashi, “Nrf2: friend or foe for chemoprevention?” Carcinogenesis, vol. 31, no. 1, pp. 90–99, 2010.
- Y. J. Surh, “NF-κB and Nrf2 as potential chemopreventive targets of some anti-inflammatory and antioxidative phytonutrients with anti-inflammatory and antioxidative activities,” Asia Pacific Journal of Clinical Nutrition, vol. 17, supplement 1, pp. 269–272, 2008.
- R. Hu, C. L. Saw, R. Yu, and A. N. Kong, “Regulation of NF-E2-related factor 2 signaling for cancer chemoprevention: antioxidant coupled with antiinflammatory,” Antioxidants & Redox Signaling, vol. 13, no. 11, pp. 1679–1698, 2010.
- J. K. Kundu and Y. J. Surh, “Nrf2-Keap1 signaling as a potential target for chemoprevention of inflammation-associated carcinogenesis,” Pharmaceutical Research, vol. 27, no. 6, pp. 999–1013, 2010.
- Y. J. Surh and H. K. Na, “NF-kappaB and Nrf2 as prime molecular targets for chemoprevention and cytoprotection with anti-inflammatory and antioxidant phytochemicals,” Genes & Nutrition, vol. 2, no. 4, pp. 313–317, 2008.
- N. H. Tung and Y. Shoyama, “New minor glycoside components from Saffron,” Journal of Natural Medicines. In press.
- R. Suzuki, H. Kohno, S. Sugie, and T. Tanaka, “Dose-dependent promoting effect of dextran sodium sulfate on mouse colon carcinogenesis initiated with azoxymethane,” Histology and Histopathology, vol. 20, pp. 483–492, 2005.
- T. Tanaka, M. Hosokawa, Y. Yasui, R. Ishigamori, and K. Miyashita, “Cancer chemopreventive ability of conjugated linolenic acids,” International Journal of Molecular Sciences, vol. 12, no. 11, pp. 7495–7509, 2011.
- M. Carmona, A. Zalacain, J. E. Pardo, E. López, A. Alvarruiz, and G. L. Alonso, “Influence of different drying and aging conditions on saffron constituents,” Journal of Agricultural and Food Chemistry, vol. 53, no. 10, pp. 3974–3979, 2005.
- P. Palozza, C. Torelli, A. Boninsegna et al., “Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells,” Cancer Letters, vol. 283, no. 1, pp. 108–117, 2009.
- S. Soeda, T. Ochiai, H. Tanaka, Y. Shoyama, and Y. Shimeno, “Prevention of ischemic neuron death by a saffron's carotenoid pigment crocin and its mechanism of action,” in Focus on Neurochemistry Research, R. M. Coleman, Ed., pp. 139–156, Nova Science, New York, NY, USA, 2005.
- V. Magesh, J. P. Vijeya Singh, K. Selvendiran, G. Ekambaram, and D. Sakthisekaran, “Antitumour activity of crocetin in accordance to tumor incidence, antioxidant status, drug metabolizing enzymes and histopathological studies,” Molecular and Cellular Biochemistry, vol. 287, no. 1-2, pp. 127–135, 2006.
- J. Sun, X. M. Xu, C. Z. Ni et al., “Crocin inhibits proliferation and nucleic acid synthesis and induces apoptosis in the human tongue squamous cell carcinoma cell line Tca8113,” The Asian Pacific Journal of Cancer Prevention, vol. 12, pp. 2679–2683, 2011.
- S. N. Goyal, S. Arora, A. K. Sharma et al., “Preventive effect of crocin of Crocus sativus on hemodynamic, biochemical, histopathological and ultrastuctural alterations in isoproterenol-induced cardiotoxicity in rats,” Phytomedicine, vol. 17, no. 3-4, pp. 227–232, 2010.
- J. K. Lin and C. J. Wang, “Protection of crocin dyes on the acute hepatic damage induced by aflatoxin B1 and dimethylnitrosamine in rats,” Carcinogenesis, vol. 7, no. 4, pp. 595–599, 1986.
- T. Tanaka and H. Ishikawa, “Mast cells and inflammation-associated colorectal carcinogenesis,” Seminars in Immunopathology. In press.
- M. Karin, “NF-kappaB as a critical link between inflammation and cancer,” Cold Spring Harbor Perspectives in Biology, vol. 1, no. 5, Article ID a000141, 2009.
- S. C. Gupta, J. H. Kim, R. Kannappan, S. Reuter, P. M. Dougherty, and B. B. Aggarwal, “Role of nuclear factor kappaB-mediated inflammatory pathways in cancer-related symptoms and their regulation by nutritional agents,” Experimental Biology and Medicine, vol. 236, no. 6, pp. 658–671, 2011.
- T. Hudcovic, R. Štěpánková, J. Cebra, and H. Tlaskalová-Hogenová, “The role of microflora in the development of intestinal inflammation: acute and chronic colitis induced by dextran sulfate in germ-free and conventionally reared immunocompetent and immunodeficient mice,” Folia Microbiologica, vol. 46, no. 6, pp. 565–572, 2001.