Topical Application of Chrysanthemum indicum L. Attenuates the Development of Atopic Dermatitis-Like Skin Lesions by Suppressing Serum IgE Levels, IFN-γ, and IL-4 in Nc/Nga Mice
Figure 1
Changes in severity scores and ear thickness of atopic dermatitis (AD) in NC/Nga mice. AD was induced in Nc/Nga mice by topical application of 2,4-dinitrochlorobenzene (DNCB) in the dorsal skin, and a right ear was topically treated with 1,3-butylen glycol (BG; control), 5% Chrysanthemum indicum L. (CIL-Low), 30% Chrysanthemum indicum L. (CIL-High), and 0.1% hydrocortisone (HC) on the lesions for 5 weeks. Normal controls did not have DCNB-induced AD. CIL decreased clinical severity of atopic dermatitis symptoms and ear thickness in a dose-dependent manner, and CIL-High had a statistically similar effect on the severity as HC. (a) Changes in severity scores. (b) Changes of ear thickness. Each value represents the mean ± SD of 10 mice in each group. *Significantly different among the different treatments in Nc/Nga mice at . a, b, c Values with different superscripts were significantly different among Nc/Nga mice by Tukey test at . †Significantly different between control (BG) and normal control at .
