Toxicological Features of Catha edulis (Khat) on Livers and Kidneys of Male and Female Sprague-Dawley Rats: A Subchronic Study

Table 1

Body weight and relative liver weight of male and female SD rats.

Dose (mg/kg)	BW (g)		ALW (g)		RLW (W/W %)
	Male	Female	Male	Female	Male	Female
NC (10 mL/kg)	200.13 ± 12.30	159.13 ± 6.98	9.57 ± 0.59	5.22 ± 0.28	3.5 ± 0.2	2.67 ± 0.10
LD (500 mg/kg)	168.25 ± 9.54	143.79 ± 5.26	6.80 ± 0.71	5.87 ± 0.29	3.1 ± 0.2	3.35 ± 0.13*
MD (1000 mg/kg)	169.54 ± 9.75	143.25 ± 4.73	7.23 ± 0.75	5.87 ± 0.27	3.2 ± 0.2	3.42 ± 0.16*
HD (2000 mg/kg)	161.42 ± 8.40*	141.08 ± 4.75	8.77 ± 0.64	7.00 ± 0.24*	4.2 ± 0.2*	4.17 ± 0.17*

BW: body weight; ALW: absolute liver weight; RLW: relative liver weight; HD: high dose; MD: medium dose; LD: low dose; NC: normal control. The treated groups received different doses of crude extract of Khat except NC which received distilled water. The values were expressed as mean ± S.E.M. the symbol (*) denoted a significant difference at P < 0.05.