Toxicological Features of Catha edulis (Khat) on Livers and Kidneys of Male and Female Sprague-Dawley Rats: A Subchronic Study
Table 2
Liver function test of male and female SD rats.
Dose (mg/kg)
ALP (IU/L)
ALT (IU/L)
AST (IU/L)
A (g/L)
TB (uM/L)
Male
Female
Male
Female
Male
Female
Male
Female
Male
Female
NC (10 mL/kg)
155.50 ± 6.22
100.83 ± 13.10
35.33 ± 2.51
39.67 ± 2.47
127.67 ± 4.48
135.17 ± 5.33
12.33 ± 1.75
15.67 ± 0.49
1.5
1.0
LD (500 mg/kg)
147.67 ± 22.31
107.67 ± 3.68
28.33 ± 3.44
25.33 ± 2.14
120.00 ± 15.64
127.00 ± 4.62
11.50 ± 2.74
12.50 ±
2.0*
2.5
MD (1000 mg/kg)
146.00 ± 16.42
149.67 ± 18.70*
27.17 ± 3.11
30.50 ± 1.52
118.33 ± 13.44
173.33 ± 10.85*
9.50 ± 2.43
13.67 ± 0.71
2.0*
2.5
HD (2000 mg/kg)
225.67 ± 19.71*
158.67 ± 10.15*
38.17 ± 1.56
31.50 ± 1.5
170.83 ± 6.30*
180.17 ±
14.00 ± 1.41
12.50 ±
3.0*
3.0
A: albumin; ALP: alkaline phosphatase; AST: aspartate aminotransferase; ALT: alanine aminotransferase; TB: total Bilirubin, HD: high dose; MD: medium dose; LD: low dose; NC: normal control. The treated groups received different doses of crude extract of khat except NC which received distilled water. The values were expressed as mean ± S.E.M. The symbol (*) denoted a significant difference P < 0.05, whereas denoted a significant difference at P ≤ 0.01.
