Toxicological Features of Catha edulis (Khat) on Livers and Kidneys of Male and Female Sprague-Dawley Rats: A Subchronic Study

Table 3

Serum enzymes of male and female SD rats.

Dose (mg/kg)	Male SD-rats		Female SD-rats
	CK (IU/L)	AM (IU/L)	CK (IU/L)	AM (IU/L)
NC (10 mL/kg)	1708.00 ± 100.61	686.00 ± 48.34	1836.33 ± 332.42	524.67 ± 31.09
LD (500 mg/kg)	1564.83 ± 73.67	731.33 ± 28.59	1380.17 ± 108.49	599.67 ± 59.78
MD (1000 mg/kg)	1699.67 ± 76.16	691.17 ± 43.61	1928.33 ± 84.34	441.83 ± 29.15
HD (2000 mg/kg)	2105.33 ± 291.87	636.67 ± 45.66	1919.17 ± 105.68	593.17 ± 64.25

AM: amylase; CK: creatine kinase; HD: high dose; MD: medium dose; LD: low dose; NC: normal control. The treated groups received different doses of crude extract of Khat except NC which received distilled water. The values were expressed as mean ± S.E.M. No significant difference was noticed between groups and normal controls, P ≥ 0.05.