Research Article

Toxicological Features of Catha edulis (Khat) on Livers and Kidneys of Male and Female Sprague-Dawley Rats: A Subchronic Study

Table 5

Renal function test of female SD rats.

Dose (mg/kg)Cr (uM/L)BUN (mM/L)Na (mM/L)K (mM/L)Cl (mM/L)CO2 (mM/L)

NC (10 mL/kg)26.17 ± 0.875.42 ± 0.23137.50 ± 3.924.55 ± 0.1698.83 ± 2.7123.18 ± 1.53
LD (500 mg/kg)33.50 ±   3.97 ± 0.11130.33 ± 2.644.63 ± 0.2490.00 ± 2.7319.83 ± 1.18
MD (1000 mg/kg)33.17 ±   4.72 ± 0.88125.17 ± 9.273.98 ± 0.3693.17 ± 9.4620.02 ± 1.69
HD (2000 mg/kg)28.67 ± 1.315.27 ± 0.51126.83 ± 9.394.12 ± 0.2291.17 ± 7.5120.08 ± 2.06

Cr: creatinine; BUN: urea; Na: Sodium; K: potassium; Cl: chloride; CO2: carbon dioxide; HD: high dose; MD: medium dose; LD: low dose; NC: normal control. The treated groups received different doses of crude extract of Khat except NC which received distilled water. The values were expressed as mean ± S.E.M. The superscript (*) indicated a significant difference, whereas (a) and (b) denoted a significant difference at P < 0.05 and P ≤ 0.01, respectively.