Toxicological Features of Catha edulis (Khat) on Livers and Kidneys of Male and Female Sprague-Dawley Rats: A Subchronic Study

Table 7

Blood film profile of female SD rats.

Dose (mg/kg)	RBC (×10^12/L)	WBC (×10^9/L)	PLT (×10^9/L)	HGB (g/L)	HCT (L/L)	MCV (fl)	MCH (pg)	MCHC (g/L)
NC (10 mL/kg)	8.24 ± 0.14	7.10 ± 0.88	616.33 ± 52.67	155.00 ± 2.35	0.51 ± 0.009	61.167 ± 0.48	18.58 ± 0.15	304.00 ± 1.37
LD (500 mg/kg)	8.22 ± 0.21	8.10 ± 0.37	727.67 ± 43.90	157.67 ± 2.91	0.51 ± 0.011	62.83 ± 0.54	19.35 ± 0.21^a∗	308.33 ± 1.78
MD (1000 mg/kg)	7.82 ± 0.21	7.95 ± 0.16	760.67 ± 16.41	161.17 ± 2.74	0.50 ± 0.009	62.67 ± 0.49	19.65 ± 0.21^b∗	315.67 ±  0.49^b∗
HD (2000 mg/kg)	7.65 ± 0.09	9.80 ± 0.67^a∗	722.67 ± 51.85	152.50 ± 1.38	0.49 ± 0.005	63.67 ± 0.42^b∗	19.97 ± 0.21^b∗	315.67 ±  2.03^b∗

RBC: red blood cells; WBC: white blood cells; PLT: platelets; HGB: hemoglobin; HCT: hematocrit; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; HD: high dose; MD: medium dose; LD: low dose; NC: normal control. The treated groups received different doses levels except NC, received distilled water. The values were expressed as mean ± S.E.M. The superscript (*) indicated a significant difference, whereas (^a) and (^b) denoted a significant difference at P < 0.05 and P ≤ 0.01, respectively.