Curative Effects of Oleanolic Acid on Formed Hypertrophic Scars in the Rabbit Ear Model

<table>Effects of oleanolic acid (OA) on the levels of collagens I (a) and III (b) and the ratio of collagens I/III (c). The levels of collagens I and III and the ratio of collagens I to III significantly increased in the control group on day 56 postoperation when compared with the normal group. The administration of OA for 28 days reversed these changes dramatically and dose dependently in comparison with the control group. <svg height="16.4" id="M17" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 74.587502 16.4" width="74.587502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared with the normal group; <svg height="13.95" id="M18" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared with the control group. Data are expressed as the mean ± SD. <svg height="11.225" id="M20" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 44.400002 11.225" width="44.400002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>.</table>

Evidence-Based Complementary and Alternative Medicine

fig1

Figure 1

Figure 1: Curative Effects of Oleanolic Acid on Formed Hypertrophic Scars in the Rabbit Ear Model 