Curative Effects of Oleanolic Acid on Formed Hypertrophic Scars in the Rabbit Ear Model
Figure 5
Masson’s trichrome staining findings for collagen. (a) Unwounded (normal) skin with regularly arranged small collagen fibers. (b) In the control group treated with ointment base, collage fibers are thicker, denser, and disorganized, the amount of which is far more than that in the normal group. (c) Contractubex. ((d)–(f)) After treatment with (d) 2.5%, (e) 5%, and (f) 10% oleanolic acid (OA) for 28 days, collagen fibers were arranged more regularly and sparse than those of the scar tissue in the control group. Original magnification ×200.
