Research Article

The Antiparkinsonian and Antidyskinetic Mechanisms of Mucuna pruriens in the MPTP-Treated Nonhuman Primate

Figure 2

(a) Firing rates of SNR and STN in the HP monkey in stable HP state (baseline) and on LD+CD (Levodopa) and MPEP+CD (Mucuna) (Kruskal-Wallis 𝑃 < 0 . 0 1 , ** 𝑃 < 0 . 0 1 rank-sum using Tukey’s HSD correction, compared to baseline HP state). (b) Poisson comparison of SNR and STN neurons Pre-LD (stable baseline HP state) (Fisher’s 2 × 2 two-sided exact test grouping “Poisson” category together with “regular,” * 𝑃 = 0 . 0 1 6 4 ), Post-LD (LD treatments), and Post-MP (MPEP+CD). (c) Coefficient of variation at HP state and with treatments (Kruskal-Wallis 𝑃 < 0 . 0 5 , * 𝑃 < 0 . 0 5 rank-sum using Tukey’s HSD correction, compared to baseline HP) (d–g) Measures of firing patterns in the SNR and STN in HP state and on treatments. (h) Sample entropy of SNR and STN.
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