Green Tea Polyphenols for the Protection against Renal Damage Caused by Oxidative Stress

Table 7

Renal functional parameters at 50 days of administration.

Items	Normal	Control	(−)-Epigallocatechin 3-O-gallate
			25 mg/kg B.W./day	50 mg/kg B.W./day	100 mg/kg B.W./day
Serum urea nitrogen (mg/dL)	16.8 ± 0.5	44.5 ± 3.1^b	37.9 ± 1.8^b,d	38.0 ± 2.6^b,d	28.8 ± 1.4^b,d
Serum Cr (mg/dL)	0.38 ± 0.01	0.94 ± 0.09^b	0.90 ± 0.08^b	0.82 ± 0.06^b	0.66 ± 0.05^b,d
Ccr (ml/kg B.W./min)	7.20 ± 0.26	3.35 ± 0.43^b	3.41 ± 0.32^b	3.65 ± 0.37^b	4.09 ± 0.35^b,c
Urinary protein (mg/day)	19.1 ± 0.7	82.3 ± 13.3^b	64.0 ± 11.9^b	47.9 ± 14.6^a,d	40.6 ± 6.4^d

Significance: ^a𝑃<0.05, ^b𝑃<0.001 versus normal values; ^c𝑃<0.05, ^d𝑃<0.001 versus diabetic nephropathy control values.