Alleviation of Morphine Withdrawal Signs but Not Tolerance by the
Essential Oil of Kelussia odoratissima Mozaff.
Figure 1
Effects of acute administration of different doses of the essential oil of K. odoratissima on the number of (a) jumps and (b) stands. Morphine was given in increasing doses over a period of 5 days. The different doses of K. odoratissima, nifedipine, and vehicle were injected in a single dose, 1 h after the final dose of morphine and 1 h prior to naloxone administration. The withdrawal signs were induced by naloxone (5 mg/kg) and recorded for 30 minutes. Results are the mean (±S.E.M.) from group of 6 mice. * for comparison with vehicle-treated group.
