Research Article

Identification of Major Active Ingredients Responsible for Burn Wound Healing of Centella asiatica Herbs

Figure 5

Effects of asiaticoside (AD), madecassoside (MD), asiatic acid (AA), and madecassic acid (MA) on TGF-β/Smad pathway in human skin fibroblasts. ((a)–(e)) The mRNA expressions of TGF-β1, TβRI, TβRII and Smad 7 were measured viaRT-PCR assay. ((f), (g)) The phosphorylation of Smad 3 was measured via Western blot assay. Each column represents the mean ± S.D. from three independent experiments. * , ** versus control.
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