Dentatin Induces Apoptosis in Prostate Cancer Cells via Bcl-2, Bcl-xL, Survivin Downregulation, Caspase-9, -3/7 Activation, and NF-κB Inhibition
Figure 3
Dentatin induces apoptosis in prostate cancer cell lines. (a) PC-3 and LNCaP cells were treated with 15 μM of dentation for 24 hours. Cells were stained with Hoechst 33342 for nucleus and Annexin V-FITC to detect apoptotic cells. (b) Fluorescence intensity of Annexin V in PC-3 or LNCaP cells treated with designated concentration of dentatin. Data were shown as mean ± SD. Significant differences between dentatin-treated and untreated control cells.
