Dentatin Induces Apoptosis in Prostate Cancer Cells via Bcl-2, Bcl-xL, Survivin Downregulation, Caspase-9, -3/7 Activation, and NF-<i>κ</i>B Inhibition

<table>Multiparameter cytotoxicity analysis of dentatin-treated PC-3 and LNCaP cells. Histogram showing the average fluorescent intensities for (a) MMP, (b) cell membrane permeability, and (c) cytochrome c. Dose-dependent decreased of MMP with increased of cell membrane permeability and cytochrome c average fluorescent intensities were observed in dentatin-treated cells. Data were shown as mean ± SD. Significant differences <svg height="16.637501" id="M9" style="vertical-align:-2.3205pt" version="1.1" viewbox="0 0 78.087502 16.637501" width="78.087502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> between dentatin-treated and untreated control cells.</table>

Evidence-Based Complementary and Alternative Medicine

fig7

Figure 7

Figure 7: Dentatin Induces Apoptosis in Prostate Cancer Cells via Bcl-2, Bcl-xL, Survivin Downregulation, Caspase-9, -3/7 Activation, and NF-<i>κ</i>B Inhibition 

Figure 7 | Dentatin Induces Apoptosis in Prostate Cancer Cells via Bcl-2, Bcl-xL, Survivin Downregulation, Caspase-9, -3/7 Activation, and NF-κB Inhibition 