Dentatin Induces Apoptosis in Prostate Cancer Cells via Bcl-2, Bcl-xL, Survivin Downregulation, Caspase-9, -3/7 Activation, and NF-κB Inhibition

Table 1

Dentatin potently inhibits growth of prostate cancer cells. IC₅₀ values of prostate cancer cells PC-3 and LNCaP in comparison to RWPE-1 normal prostate epithelial cells at 24, 48 and 72 hours post dentatin treatment.

		Dentatin (μM)
	24 hours	48 hours	72 hours
PC-3	9.60 ± 1.53	8.15 ± 2.41	3.47 ± 0.58
LNCaP	7.32 ± 2.56	6.79 ± 1.90	3.76 ± 1.21
RWPE-1	24.30 ± 2.62	24.98 ± 3.93	22.08 ± 2.68