Aqueous Extract of Solanum nigrum Leaf Activates Autophagic Cell Death and Enhances Docetaxel-Induced Cytotoxicity in Human Endometrial Carcinoma Cells
Figure 1
Cytotoxicity of AE-SN in human endometrial cancer cells. (a–c) Results of MTT assay in HEC1A, HEC1B, and KLE cells. Cells were treated with 0, 0.05, 0.1, 0.2, 0.5, 1, 2 or 5 mg/mL AE-SN for 24, 48, or 72 hr. All three cell lines showed dose-dependent effects with AE-SN treatment at the three time points, as shown by one way ANOVA (). (d) Trypan blue exclusion test in HEC1A, HEC1B, and KLE cells. HEC1A and HEC1B cells were treated with 0, 0.1 or 0.5 mg/mL AE-SN, whereas KLE cells were treated with 0.5 and 2 mg/mL AE-SN for 48 hr. All three cell lines showed dose-dependent effects with AE-SN treatment, as shown by one-way ANOVA (, 0.043, and 0.001 for HEC1A, HEC1B, and KLE cells, resp.). Experiments were done in triplicate, and all data are presented as .
