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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 872458, 8 pages
http://dx.doi.org/10.1155/2012/872458
Research Article

Active Hydrophilic Components of the Medicinal Herb Salvia miltiorrhiza (Danshen) Potently Inhibit Organic Anion Transporters 1 (Slc22a6) and 3 (Slc22a8)

Department of Pharmaceutics, Virginia Commonwealth University, 410 N 12th Street, Richmond, VA 23298, USA

Received 19 April 2012; Revised 25 May 2012; Accepted 31 May 2012

Academic Editor: Youn Chul Kim

Copyright © 2012 Li Wang and Douglas H. Sweet. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [8 citations]

The following is the list of published articles that have cited the current article.

  • Dhanapalan Karthik, Elumalai Arunkumar, Periasamy Viswanathan, and Carani Venkatraman Anuradha, “Rosmarinic acid treatment alleviates fibrotic changes in the myocardium induced in a rat model of insulin resistance,” Asian Pacific Journal of Tropical Disease, vol. 2, pp. S920–S926, 2012. View at PublisherView at Google Scholar
  • Li Wang, Xiaolei Pan, and Douglas H. Sweet, “The anthraquinone drug rhein potently interferes with organic anion transporter-mediated renal elimination,” Biochemical Pharmacology, 2013. View at PublisherView at Google Scholar
  • Aditi Mulgaonkar, Juergen Venitz, Dirk Gruendemann, and Douglas H. Sweet, “Human Organic Cation Transporters 1 (SLC22A1), 2 (SLC22A2), and 3 (SLC22A3) as Disposition Pathways for Fluoroquinolone Antimicrobials,” Antimicrobial Agents And Chemotherapy, vol. 57, no. 6, pp. 2705–2711, 2013. View at PublisherView at Google Scholar
  • Li Wang, and Douglas H. Sweet, “Renal Organic Anion Transporters (SLC22 Family): Expression, Regulation, Roles in Toxicity, and Impact on Injury and Disease,” Aaps Journal, vol. 15, no. 1, pp. 53–69, 2013. View at PublisherView at Google Scholar
  • Li Wang, and Douglas H. Sweet, “Competitive Inhibition of Human Organic Anion Transporters 1 (SLC22A6), 3 (SLC22A8) and 4 (SLC22A11) by Major Components of the Medicinal Herb Salvia miltiorrhiza (Danshen),” Drug Metabolism And Pharmacokinetics, vol. 28, no. 3, pp. 220–228, 2013. View at PublisherView at Google Scholar
  • Li Wang, and Douglas H. Sweet, “Interaction of Natural Dietary and Herbal Anionic Compounds and Flavonoids with Human Organic Anion Transporters 1 (SLC22A6), 3 (SLC22A8), and 4 (SLC22A11),” Evidence-Based Complementary and Alternative Medicine, vol. 2013, pp. 1–7, 2013. View at PublisherView at Google Scholar
  • Matthew S. Halquist, Douglas H. Sweet, and Li Wang, “Simultaneous determination of gallic acid and gentisic acid in organic anion transporter expressing cells by liquid chromatography-tandem mass spectrometry,” Journal Of Chromatography B-Analytical Technologies In The Biomedical And L, vol. 937, pp. 91–96, 2013. View at PublisherView at Google Scholar
  • Maria L. M. Serralheiro, Pedro L. Fale, and Lia Ascensao, “Effect of luteolin and apigenin on rosmarinic acid bioavailability in Caco-2 cell monolayers,” Food & Function, vol. 4, no. 3, pp. 426–431, 2013. View at PublisherView at Google Scholar