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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 872458, 8 pages
Active Hydrophilic Components of the Medicinal Herb Salvia miltiorrhiza (Danshen) Potently Inhibit Organic Anion Transporters 1 (Slc22a6) and 3 (Slc22a8)
Department of Pharmaceutics, Virginia Commonwealth University, 410 N 12th Street, Richmond, VA 23298, USA
Received 19 April 2012; Revised 25 May 2012; Accepted 31 May 2012
Academic Editor: Youn Chul Kim
Copyright © 2012 Li Wang and Douglas H. Sweet. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- L. Zhou, Z. Zuo, and M. S. S. Chow, “Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use,” Journal of Clinical Pharmacology, vol. 45, no. 12, pp. 1345–1359, 2005.
- T. O. Cheng, “Cardiovascular effects of Danshen,” International Journal of Cardiology, vol. 121, no. 1, pp. 9–22, 2007.
- R. W. Jiang, K. M. Lau, P. M. Hon, T. C. W. Mak, K. S. Woo, and K. P. Fung, “Chemistry and biological activities of caffeic acid derivatives from Salvia miltiorrhiza,” Current Medicinal Chemistry, vol. 12, no. 2, pp. 237–246, 2005.
- D. Yuan, Y. N. Pan, W. W. Fu, T. Makino, and Y. Kano, “Quantitative analysis of the marker compounds in Salvia miltiorrhiza root and its phytomedicinal preparations,” Chemical and Pharmaceutical Bulletin, vol. 53, no. 5, pp. 508–514, 2005.
- X. Li, C. Yu, Y. Cai, G. Liu, J. Jia, and Y. Wang, “Simultaneous determination of six phenolic constituents of danshen in human serum using liquid chromatography/tandem mass spectrometry,” Journal of Chromatography B, vol. 820, no. 1, pp. 41–47, 2005.
- J. L. Zhang, M. Cui, Y. He, H. L. Yu, and D. A. Guo, “Chemical fingerprint and metabolic fingerprint analysis of Danshen injection by HPLC-UV and HPLC-MS methods,” Journal of Pharmaceutical and Biomedical Analysis, vol. 36, no. 5, pp. 1029–1035, 2005.
- A. L. VanWert, M. R. Gionfriddo, and D. H. Sweet, “Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology,” Biopharmaceutics and Drug Disposition, vol. 31, no. 1, pp. 1–71, 2010.
- D. H. Sweet, K. T. Bush, and S. K. Nigam, “The organic anion transporter family: from physiology to ontogeny and the clinic,” American Journal of Physiology-Renal Physiology, vol. 281, no. 2, pp. F197–F205, 2001.
- D. H. Sweet, “Organic anion transporter (Slc22a) family members as mediators of toxicity,” Toxicology and Applied Pharmacology, vol. 204, no. 3, pp. 198–215, 2005.
- K. G. Dickman, D. H. Sweet, R. Bonala, T. Ray, and A. Wu, “Physiological and molecular characterization of aristolochic acid transport by the kidney,” Journal of Pharmacology and Experimental Therapeutics, vol. 338, no. 2, pp. 588–597, 2011.
- D. H. Sweet, N. A. Wolff, and J. B. Pritchard, “Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney,” Journal of Biological Chemistry, vol. 272, no. 48, pp. 30088–30095, 1997.
- D. H. Sweet, L. M. S. Chan, R. Walden, X. P. Yang, D. S. Miller, and J. B. Pritchard, “Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient,” American Journal of Physiology-Renal Physiology, vol. 284, no. 4, pp. F763–F769, 2003.
- A. L. VanWert and D. H. Sweet, “Impaired clearance of methotrexate in organic anion transporter 3 (Slc22a8) knockout mice: a gender specific impact of reduced folates,” Pharmaceutical Research, vol. 25, no. 2, pp. 453–462, 2008.
- A. L. VanWert, R. M. Bailey, and D. H. Sweet, “Organic anion transporter 3 (Oat3/Slc22a8) knockout mice exhibit altered clearance and distribution of penicillin G,” American Journal of Physiology-Renal Physiology, vol. 293, no. 4, pp. F1332–F1341, 2007.
- A. L. VanWert, C. Srimaroeng, and D. H. Sweet, “Organic anion transporter 3 (Oat3/Slc22a8) interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacin,” Molecular Pharmacology, vol. 74, no. 1, pp. 122–131, 2008.
- S. A. Eraly, V. Vallon, D. A. Vaughn et al., “Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice,” Journal of Biological Chemistry, vol. 281, no. 8, pp. 5072–5083, 2006.
- G. W. Schnabolk, B. Gupta, A. Mulgaonkar, M. Kulkarni, and D. H. Sweet, “Organic anion transporter 6 (Slc22a20) specificity and sertoli cell-specific expression provide new insight on potential endogenous roles,” Journal of Pharmacology and Experimental Therapeutics, vol. 334, no. 3, pp. 927–935, 2010.
- R. Copeland, Enzymes: A Practical Introduction to Structure, Mechanism, and Data Analysis, Chapter 8, Wiley-VCH Press, Cambridge, UK, 2000.
- Y. Cheng and W. H. Prusoff, “Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction,” Biochemical Pharmacology, vol. 22, no. 23, pp. 3099–3108, 1973.
- S. Bent, “Herbal medicine in the United States: review of efficacy, safety, and regulation: grand rounds at University of California, San Francisco Medical Center,” Journal of General Internal Medicine, vol. 23, no. 6, pp. 854–859, 2008.
- A. C. Whitley, D. H. Sweet, and T. Walle, “The dietary polyphenol ellagic acid is a potent inhibitor of hOAT1,” Drug Metabolism and Disposition, vol. 33, no. 8, pp. 1097–1100, 2005.
- K. G. Dickman, R. Bonala, T. Ray, et al., “Aristolochic acid I is a substrate for mouse organic anion transporters: a basis for selective proximal tubule toxicity,” Journal of the American Society of Nephrology, vol. 19, p. 359A, 2008.
- G. Kaler, D. M. Truong, A. Khandelwal et al., “Structural variation governs substrate specificity for Organic Anion Transporter (OAT) homologs: potential remote sensing by OAT family members,” Journal of Biological Chemistry, vol. 282, no. 33, pp. 23841–23853, 2007.
- S. A. Eraly, “Organic anion transporter 3 inhibitors as potential novel antihypertensives,” Pharmacological Research, vol. 58, no. 5-6, pp. 257–261, 2008.
- T. Lu, J. Yang, X. Gao et al., “Plasma and urinary tanshinol from Salvia miltiorrhiza (Danshen) can be used as pharmacokinetic markers for cardiotonic pills, a cardiovascular herbal medicine,” Drug Metabolism and Disposition, vol. 36, no. 8, pp. 1578–1586, 2008.
- B. B. Chang, L. Zhang, W. W. Cao et al., “Pharmacokinetic interactions induced by content variation of major water-soluble components of Danshen preparation in rats,” Acta Pharmacologica Sinica, vol. 31, no. 5, pp. 638–646, 2010.
- U. S. Department of Health and Human Services and Food and Drug Administration, Guidance for Industry: Drug Interaction Studies-Study Design, Data Analysis, Implications for Dosing, and Labeling Recommendations, http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM292362.pdf, 2012.
- C. C. Wong, D. Barron, C. Orfila, F. Dionisi, P. Krajcsi, and G. Williamson, “Interaction of hydroxycinnamic acids and their conjugates with organic anion transporters and ATP-binding cassette transporters,” Molecular Nutrition and Food Research, vol. 55, no. 7, pp. 979–988, 2011.
- C. C. Wong, N. P. Botting, C. Orfila, N. Al-Maharik, and G. Williamson, “Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6),” Biochemical Pharmacology, vol. 81, no. 7, pp. 942–949, 2011.
- S. Baba, N. Osakabe, M. Natsume et al., “Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans,” European Journal of Nutrition, vol. 44, no. 1, pp. 1–9, 2005.
- T. Nakazawa and K. Ohsawa, “Metabolism of rosmarinic acid in rats,” Journal of Natural Products, vol. 61, no. 8, pp. 993–996, 1998.
- Y. Shen, X. Wang, L. Xu, X. Liu, and R. Chao, “Characterization of metabolites in rat plasma after intravenous administration of salvianolic acid A by liquid chromatography/time-of-flight mass spectrometry and liquid chromatography/ion trap mass spectrometry,” Rapid Communications in Mass Spectrometry, vol. 23, no. 12, pp. 1810–1816, 2009.
- D. Zhao, Z. D. Gao, D. E. Han et al., “Influence of rifampicin on the pharmacokinetics of salvianolic acid B may involve inhibition of organic anion transporting polypeptide (Oatp) mediated influx,” Phytotherapy Research, vol. 26, no. 1, pp. 118–121, 2012.