Meta-Analysis of Randomized Controlled Trials on the Efficacy of Di’ao Xinxuekang Capsule and Isosorbide Dinitrate in Treating Angina Pectoris
Table 2
Subgroups and sensitivity analysis based on ORs of SYMPTOMS outcomes.
Group
No. of studies
No. of participants
OR
Wilcoxon test
95% CI
(effect)
(het)
M score
≤3
5
432
4.76
2.85, 7.95
5.96
<0.00001
0%
2.21
0.70
>3
2
118
2.24
6
0.41, 12.17
0.94
0.35
67%
3.06
0.08
Sample size
<78
4
214
2.49
1.09, 5.68
2.17
0.03
3%
3.09
0.38
≥78
3
336
5.22
5
3.05, 8.93
6.03
<0.00001
0%
1.07
0.59
No. of authors
1
4
396
4.85
2.90, 8.11
6.01
<0.00001
0%
1.94
0.58
>1
3
154
2.61
0.82, 8.36
1.62
0.11
35%
3.06
0.22
Publication year
<2005
4
346
3.84
1.65, 8.93
3.12
0.002
47%
5.71
0.13
≥2005
3
204
3.82
7
1.78, 8.21
3.44
0.0006
0%
0.58
0.75
Trial date
Reported
5
432
4.76
2.85, 7.95
5.96
<0.000 01
0%
2.21
0.70
Not reported
2
118
2.24
6
0.41, 12.17
0.94
0.35
67%
3.06
0.08
Comparable
Reported
4
238
2.83
1.36, 5.89
2.78
0.005
10%
3.35
0.34
Not reported
3
312
5.45
3
3.02, 9.83
5.64
<0.00001
0%
1.12
0.57
AEs
Reported
4
310
3.30
1.58, 6.88
3.18
0.0001
21%
3.78
0.29
Not reported
3
240
5.17
2.74, 9.78
5.06
<0.00001
0%
1.71
0.43
Improvement
>50%
7
550
4.11
2.57, 6.55
5.93
<0.00001
6%
6.36
0.38
>80%
5
370
1.83
6
1.20, 2.82
2.77
0.006
0%
1.10
0.89
CI is confidence interval. Mann-Whitney-Wilcoxon test was performed on ORs of SYMPTOMS. and (effect) evaluated the statistics of overall effect; , , and (het) were computed to assess heterogeneity.
