The Cortical and Striatal Gene Expression Profile of 100 Hz Electroacupuncture Treatment in 6-Hydroxydopamine-Induced Parkinson's Disease Model

Figure 3

STC analyzed for differential genes in the cortex and STR after 6-OHDA or 6-OHDA/EA treatment. There were 16 types of profiles for differential genes in three experimental groups of the cortex or STR (control, model, and EA group). The number on the 𝑌-axis is the degree of change and not a concrete value. These profiles can be divided into 5 subgroups. (a) Recovery expression profiles group ((a), (A)–(F)). After EA treatment, these genes tended to recover the normal level. Genes of (a)-(A) and (B) were completely recovered. Genes of (a)-(C) and (D), however, were only partially recovered. (a)-(E) and (F) represent the overcorrect genes. (b) Upregulated group ((b), (A)–(C)). These genes continued to be upregulated after EA treatment. (c) Downregulated group ((c), (A)–(C)). These genes continued to be downregulated after EA treatment. These two part of genes ((b) and (c)) need to be considered individually and they belong to the portion of genes regulated by EA. (d) This group was only regulated by EA ((d)-(A) and (d)-(B)). These genes were up- or downregulated only after 100 Hz EA treatment. (e) The group continued to maintain the model group level. These genes displayed no change after EA treatment but were upregulated or downregulated compared to control. A detailed functional annotation is displayed (see Tables S2–8 in supplementary material available on line at doi:10.1155/2012/908439) and it shows that the target genes of 100 Hz EA are extensive and involved in multifunctional regulation.