- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Recently Accepted Articles ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 912028, 7 pages
Topical Apigenin Alleviates Cutaneous Inflammation in Murine Models
1The Center for Skin Physiology Research, Dalian Skin Disease Hospital, Liaoning 116021, China
2Dermatology Service, Veterans Affairs Medical Center and Department of Dermatology, University of California, San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
Received 24 July 2012; Revised 10 October 2012; Accepted 18 October 2012
Academic Editor: Wagner Vilegas
Copyright © 2012 Mao-Qiang Man et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- W. Man, M. Man, M. Hupe, et al., “Topical herbal extract (Huangdang mixture) exhibits both preventive and therapeutic effects in murine acute irritant contact dermatitis,” International Journal of Dermatology, vol. 50, no. 11, pp. 1421–1427, 2011.
- C. F. Kuo, C. C. Chen, Y. H. Luo et al., “Cordyceps sinensis mycelium protects mice from group A streptococcal infection,” Journal of Medical Microbiology, vol. 54, Part 8, pp. 795–802, 2005.
- M. Minami, M. Ichikawa, N. Hata, and T. Hasegawa, “Protective effect of hainosankyuto, a traditional japanese medicine, on streptococcus pyogenes infection in murine model,” PLoS ONE, vol. 6, no. 7, article e22188, 2011.
- S. J. Lee, S. G. Oh, S. W. Seo et al., “Oral administration of Astragalus membranaceus inhibits the development of DNFB-induced dermatitis in NC/Nga mice,” Biological and Pharmaceutical Bulletin, vol. 30, no. 8, pp. 1468–1471, 2007.
- R. R. Korać and K. M. Khambholja, “Potential of herbs in skin protection from ultraviolet radiation,” Pharmacognosy Reviews, vol. 5, no. 10, pp. 164–173, 2011.
- M. Vaid, S. D. Sharma, and S. K. Katiyar, “Honokiol, a phytochemical from the Magnolia plant, inhibits photocarcinogenesis by targeting UVB-induced inflammatory mediators and cell cycle regulators: development of topical formulation,” Carcinogenesis, vol. 31, no. 11, pp. 2004–2011, 2010.
- Y. P. Hwang, J. H. Choi, and H. G. Kim, “et al. Cultivated ginseng suppresses ultraviolet B-induced collagenase activation via mitogen-activated protein kinases and nuclear factor κB/activator protein-1-dependent signaling in human dermal fibroblasts,” Nutrition Research, vol. 32, no. 6, pp. 428–438, 2012.
- S. J. Suh, J. W. Yoon, T. K. Lee et al., “Chemoprevention of Scutellaria bardata on human cancer cells and tumorigenesis in skin cancer,” Phytotherapy Research, vol. 21, no. 2, pp. 135–141, 2007.
- M. Q. Man, Y. Shi, M. Man et al., “Chinese herbal medicine (Tuhuai extract) exhibits topical anti-proliferative and anti-inflammatory activity in murine disease models,” Experimental Dermatology, vol. 17, no. 8, pp. 681–687, 2008.
- Y. Y. Sung, T. Yoon, J. Y. Jang, S. J. Park, and H. K. Kim, “Topical application of Rehmannia glutinosa extract inhibits mite allergen-induced atopic dermatitis in NC/Nga mice,” Journal of Ethnopharmacology, vol. 134, no. 1, pp. 37–44, 2011.
- T. Yoon, D. Y. Lee, A. Y. Lee, G. Choi, B. K. Choo, and H. K. Kim, “Anti-inflammatory effects of Glehnia littoralis extract in acute and chronic cutaneous inflammation,” Immunopharmacology and Immunotoxicology, vol. 32, no. 4, pp. 663–670, 2010.
- T. H. Chung, T. J. Kang, W. K. Cho, et al., “Effectiveness of the novel Herbal medicine, KIOM-MA, and its bioconversion product, KIOM-MA128, on the treatment of atopic dermatitis,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 762918, 9 pages, 2012.
- G. A. Johnston, R. M. Bilbao, and R. A. C. Graham-Brown, “The use of complementary medicine in children with atopic dermatitis in secondary care in Leicester,” British Journal of Dermatology, vol. 149, no. 3, pp. 566–571, 2003.
- H. M. Cheng, L. C. Chiang, Y. M. Jan, G. W. Chen, and T. C. Li, “The efficacy and safety of a Chinese herbal product (Xiao-Feng-San) for the treatment of refractory atopic dermatitis: a randomized, double-blind, placebo-controlled trial,” International Archives of Allergy and Immunology, vol. 155, no. 2, pp. 141–148, 2011.
- B. H. May, A. L. Zhang, W. Zhou, C. J. Lu, S. Deng, and C. C. Xue, “Oral herbal medicines for psoriasis: a review of clinical studies,” Chinese Journal of Integrative Medicine, vol. 18, pp. 172–178, 2012.
- Y. S. Bai, C. Y. Zhou, and J. Q. Wang, “Clinical observation on auxiliary treatment of hormone dependence dermatitis by shufeng liangxue decoction,” Zhongguo Zhong Xi Yi Jie He Za Zhi, vol. 28, no. 12, pp. 1121–1123, 2008.
- S. Y. Chen, W. M. Song, and X. H. Du, “Effect of modified wuhua decoction on skin barrier function in facial corticosteroid addictive dermatitis patients,” Zhongguo Zhong Xi Yi Jie He Za Zhi, vol. 28, no. 5, pp. 410–413, 2008.
- D. Y. Lee, G. Choi, T. Yoon, M. S. Cheon, B. K. Choo, and H. K. Kim, “Anti-inflammatory activity of Chrysanthemum indicum extract in acute and chronic cutaneous inflammation,” Journal of Ethnopharmacology, vol. 123, no. 1, pp. 149–154, 2009.
- F. Yuan, “Nursing care for babies with diaper dermatitis treated with chrysanthemum flower water,” China Foreign Medical Treatment, vol. 13, article 117, 2010.
- T. Sun, L. Meng, and S. Wang, “Bathing with different concentrations of wild chrysanthemum soup for newborn erythema venenatum: comparison of the effect,” Journal of Nursing Sciences, vol. 32, pp. 39–40, 2011.
- M. Zhou, “Treatment of drug dermatitis with chrysanthemum bathing,” Jiangxi Journal of Traditional Chinese Medicine, vol. 32, pp. 60–61, 2001.
- J. Zhang, D. W. Qiang, Y. B. Li, and Z. Q. Duan, “Chemical constituents from chrysanthemum morifolium ramat,” Natural Product Research and Development, vol. 18, pp. 71–73, 2006.
- H. Shen, Q. Guo, H. Fang, Y. Wang, and M. Jin, “Determination of quercetin, luteolin, apigenin and acacetin in Flos Chrysanthemi Indici by RP-HPLC,” Zhongguo Zhongyao Zazhi, vol. 35, no. 2, pp. 191–193, 2010.
- X. Tong, R. T. Van Dross, A. Abu-Yousif, A. R. Morrison, and J. C. Pelling, “Apigenin prevents UVB-induced cyclooxygenase 2 expression: coupled mRNA stabilization and translational inhibition,” Molecular and Cellular Biology, vol. 27, no. 1, pp. 283–296, 2007.
- R. T. Van Dross, X. Hong, S. Essengue, S. M. Fischer, and J. C. Pelling, “Modulation of UVB-induced and basal cyclooxygenase-2 (COX-2) expression by apigenin in mouse keratinocytes: role of USF transcription factors,” Molecular Carcinogenesis, vol. 46, no. 4, pp. 303–314, 2007.
- S. Yano, D. Umeda, S. Yamashita, K. Yamada, and H. Tachibana, “Dietary apigenin attenuates the development of atopic dermatitis-like skin lesions in NC/Nga mice,” Journal of Nutritional Biochemistry, vol. 20, no. 11, pp. 876–881, 2009.
- I. Arsić, V. Tadić, D. Vlaović et al., “Preparation of novel apigenin-enriched, liposomal and non-liposomal, antiinflammatory topical formulations as substitutes for corticosteroid therapy,” Phytotherapy Research, vol. 25, no. 2, pp. 228–233, 2011.
- M. Schmuth, C. M. Haqq, W. J. Cairns, et al., “Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes,” Journal of Investigative Dermatology, vol. 122, pp. 971–983, 2004.
- L. G. Komuves, K. Hanley, A. M. Lefebvre, et al., “Stimulation of PPARalpha promotes epidermal keratinocyte differentiation in vivo,” Journal of Investigative Dermatology, vol. 115, pp. 353–360, 2000.
- M. Q. Man, Y. Hatano, S. H. Lee et al., “Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges,” Journal of Investigative Dermatology, vol. 128, no. 1, pp. 79–86, 2008.
- M. Hou, M. Man, W. Man et al., “Topical hesperidin improves epidermal permeability barrier function and epidermal differentiation in normal murine skin,” Experimental Dermatology, vol. 21, pp. 337–340, 2012.
- M. Man, M. Hupe, D. Mackenzie et al., “A topical Chinese herbal mixture improves epidermal permeability barrier function in normal murine skin,” Experimental Dermatology, vol. 20, no. 3, pp. 285–288, 2011.
- I. Nemoto-Hasebe, M. Akiyama, T. Nomura, A. Sandilands, W. H. I. McLean, and H. Shimizu, “Clinical severity correlates with impaired barrier in filaggrin-related eczema,” Journal of Investigative Dermatology, vol. 129, no. 3, pp. 682–689, 2009.
- Y. Hatano, M. Q. Man, Y. Uchida, et al., “Murine atopic dermatitis responds to peroxisome proliferator-activated receptor alpha, ß/delta (but not gamma), and liver-X-receptor activators,” Journal of Allergy and Clinical Immunology, vol. 125, pp. 160–169, 2010.
- T. Knor, A. Meholjić-Fetahović, and A. Mehmedagić, “Stratum corneum hydration and skin surface pH in patients with atopic dermatitis,” Acta Dermatovenerologica Croatica, vol. 19, pp. 242–247, 2011.
- Y. Herouy, P. Mellios, E. Bandemir et al., “Inflammation in stasis dermatitis upregulates MMP-1, MMP-2 and MMP-13 expression,” Journal of Dermatological Science, vol. 25, no. 3, pp. 198–205, 2001.
- E. N. Unemori, N. Ehsani, M. Wang, S. Lee, J. McGuire, and E. P. Amento, “Interleukin-1 and transforming growth factor-α: synergistic stimulation of metalloproteinases, PGE2, and proliferation in human fibroblasts,” Experimental Cell Research, vol. 210, no. 2, pp. 166–171, 1994.
- H. Lim and H. P. Kim, “Inhibition of mammalian collagenase, matrix metalloproteinase-1, by naturally-occurring flavonoids,” Planta Medica, vol. 73, no. 12, pp. 1267–1274, 2007.
- A. Xagorari, A. Papapetropoulos, A. Mauromatis, M. Economou, T. Fotsis, and C. Roussos, “Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages,” Journal of Pharmacology and Experimental Therapeutics, vol. 296, no. 1, pp. 181–187, 2001.
- J. Kowalski, A. Samojedny, M. Paul, G. Pietsz, and T. Wilczok, “Effect of apigenin, kaempferol and resveratrol on the expression of interleukin-1β and tumor necrosis factor-α genes in J774.2 macrophages,” Pharmacological Reports, vol. 57, no. 3, pp. 390–394, 2005.
- H. Ueda, C. Yamazaki, and M. Yamazaki, “A hydroxyl group of flavonoids affects oral anti-inflammatory activity and inhibition of systemic tumor necrosis factor-α production,” Bioscience, Biotechnology and Biochemistry, vol. 68, no. 1, pp. 119–125, 2004.
- M. E. Gerritsen, W. W. Carley, G. E. Ranges et al., “Flavonoids inhibit cytokine-induced endothelial cell adhesion protein gene expression,” American Journal of Pathology, vol. 147, no. 2, pp. 278–292, 1995.
- Y. Takano-Ishikawa, M. Goto, and K. Yamaki, “Inhibitory Effects of Several Flavonoids on E-selectin Expression on Human Umbilical Vein Endothelial Cells Stimulated by Tumor Necrosis Factor-α,” Phytotherapy Research, vol. 17, no. 10, pp. 1224–1227, 2003.
- M. S. Cheon, T. Yoon, D. Y. Lee et al., “Chrysanthemum indicum Linné extract inhibits the inflammatory response by suppressing NF-κB and MAPKs activation in lipopolysaccharide-induced RAW 264.7 macrophages,” Journal of Ethnopharmacology, vol. 122, no. 3, pp. 473–477, 2009.
- C. Xie, J. Kang, Z. Li, et al., “The açaí flavonoid velutin is a potent anti-inflammatory agent: blockade of LPS-mediated TNF-α and IL-6 production through inhibiting NF-κB activation and MAPK pathway,” The Journal of Nutritional Biochemistry, vol. 23, pp. 1184–1191, 2012.
- M. I. Khalil, N. Alam, M. Moniruzzaman, S. A. Sulaiman, and S. H. Gan, “Phenolic acid composition and antioxidant properties of malaysian honeys,” Journal of Food Science, vol. 76, no. 6, pp. C921–C928, 2011.
- D. Romanová, A. Vachálková, L. Cipák, Z. Ovesná, and P. Rauko, “Study of antioxidant effect of apigenin, luteolin and quercetin by DNA protective method,” Neoplasma, vol. 48, no. 2, pp. 104–107, 2001.
- Z. Weng, B. Zhang, S. Asadi et al., “Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans,” PLoS One, vol. 7, article e33805, 2012.
- D. Hayashi, H. Sugaya, T. Ohkoshi et al., “Vitamin E improves biochemical indices associated with symptoms of atopic dermatitis-like inflammation in NC/Nga mice,” Journal of Nutritional Science and Vitaminology, vol. 58, pp. 161–168, 2012.
- J. Gupta, E. Grube, M. B. Ericksen, et al., “Intrinsically defective skin barrier function in children with atopic dermatitis correlates with disease severity,” Journal of Allergy and Clinical Immunology, vol. 121, no. 3, pp. 725–730, 2008.
- D. W. Kim, J. Y. Park, G. Y. Na, S. J. Lee, and W. J. Lee, “Correlation of clinical features and skin barrier function in adolescent and adult patients with atopic dermatitis,” International Journal of Dermatology, vol. 45, no. 6, pp. 698–701, 2006.
- T. K. M. Le, P. De Mon, J. Schalkwijk, and P. G. M. Van Der Valk, “Effect of a topical corticosteroid, a retinoid and a vitamin D3 derivative on sodium dodecyl sulphate induced skin irritation,” Contact Dermatitis, vol. 37, no. 1, pp. 19–26, 1997.
- A. Parneix-Spake, P. Goustas, and R. Green, “Eumovate (clobetasone butyrate) 0.05% cream with its moisturizing emollient base has better healing properties than hydrocortisone 1% cream: a study in nickel-induced contact dermatitis,” Journal of Dermatological Treatment, vol. 12, no. 4, pp. 191–197, 2001.
- K. S. Suh, S. Oh, J. T. Woo, et al., “Apigenin attenuates 2-deoxy-D-ribose-induced oxidative cell damage in HIT-T15 pancreatic β-cells,” Biological and Pharmaceutical Bulletin, vol. 35, pp. 121–126, 2012.
- B. H. Jin, L. B. Qian, S. Chen et al., “Apigenin protects endothelium-dependent relaxation of rat aorta against oxidative stress,” European Journal of Pharmacology, vol. 616, no. 1–3, pp. 200–205, 2009.
- L. Al-Shaal, R. Shegokar, and R. H. Muller, “Production and characterization of antioxidant apigenin nanocrystals as a novel UV skin protective formulation,” International Journal of Pharmaceutics, vol. 420, pp. 133–140, 2011.
- S. Pasonen-Seppänen, M. T. Suhonen, M. Kirjavainen et al., “Vitamin C enhances differentiation of a continuous keratinocyte cell line (REK) into epidermis with normal stratum corneum ultrastructure and functional permeability barrier,” Histochemistry and Cell Biology, vol. 116, no. 4, pp. 287–297, 2001.
- H. Y. Jeon, J. K. Kim, W. G. Kim, and S. J. Lee, “Effects of oral epigallocatechin gallate supplementation on the minimal erythema dose and uv-induced skin damage,” Skin Pharmacology and Physiology, vol. 22, no. 3, pp. 137–141, 2009.
- H. Jerajani, H. Mizoguchi, J. Li, D. Whittenbarger, and M. Marmor, “The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: a randomized, double-blind trial,” Indian Journal of Dermatology, Venereology and Leprology, vol. 76, no. 1, pp. 20–26, 2010.
- P. Singh, S. K. Mishra, S. Noel, S. Sharma, and S. K. Rath, “Acute exposure of apigenin induces hepatotoxicity in Swiss mice,” PLoS One, vol. 7, article e31964, 2012.
- K. N. Rithidech, M. Tungjai, P. Reungpatthanaphong, L. Honikel, and S. R. Simon, “Attenuation of oxidative damage and inflammatory responses by apigenin given to mice after irradiation,” Mutation Research, vol. 749, no. 1-2, pp. 29–38, 2012.