Copaiba Oil-Resin Treatment Is Neuroprotective and Reduces Neutrophil Recruitment and Microglia Activation after Motor Cortex Excitotoxic Injury
Figure 2
COR treatment reduces neutrophil infiltration at 1 day following cortical damage, as revealed by antineutrophil immunohistochemistry. Animals treated with 5% tween (a-b) or 400 mg/kg of COR (c-d). COR treatment reduced neutrophil infiltration (c-d) compared to vehicle animals (a-b), as confirmed by quantitative analysis (e, , Student’s t-test). Arrows point to MBS-1+ cells (neutrophils). Asterisks indicate the excitotoxic necrotic center. Scale bars: (a–c) (300 μm); (b–d) (50 μm).
