Chinese Herbal Formula Xiao Yao San for Treatment of Depression: A Systematic Review of Randomized Controlled Trials

Table 5

Analyses of score of HAMD.

Trials		WMD [95% CI]	P value
Xiaoyao powder versus antidepressants
Danzhi Xiaoyao powder versus maprotiline	2	2.39 [−0.55, 5.33]	0.11
Modified Xiaoyao powder versus amitriptyline	1	1.11 [−0.21, 2.43]	0.10
Xiaoyao powder versus fluoxetine	1	−3.30 [−6.07, −0.53]	0.02
Meta-Analysis [FEM]	4	0.59 [−0.51, 1.70]	0.29
Meta-Analysis [REM]	4	0.43 [−2.14, 2.99]	0.74
Xiaoyao powder plus antidepressants versus antidepressants
Xiaoyao pills plus fluoxetine versus amitriptyline	1	0.06 [−1.50, 1.62]	0.94
Xiaoyao pills plus fluoxetine versus paroxetine	1	1.88 [0.20, 3.56]	0.03
Danzhi Xiaoyao decoction/powder plus fluoxetine versus fluoxetine	2	−0.18 [−0.49, 0.13]	0.25
Xiaoyao pills plus imipramine versus imipramine	1	−0.10 [−2.35, 2.15]	0.93
Xiaoyao pills plus fluoxetine versus fluoxetine	3	−1.41 [−2.17, −0.65]	0.0003
Danzhi Xiaoyao powder plus amitriptyline versus amitriptyline	1	−5.84 [−8.76, −2.92]	<0.0001
Xiaoyao pills plus citalopram versus citalopram	1	−0.30 [−2.06, 1.46]	0.74
Xiaoyao pills plus doxepin versus fluoxetine	1	−0.88 [−1.38, −0.38]	0.0006
Modified Xiaoyao pills plus amitriptyline versus fluoxetine	1	0.17 [−1.29, 1.63]	0.82
Xiaoyao powder plus doxepin versus doxepin	1	−0.80 [−4.84, 3.24]	0.70
Modified Xiaoyao powder plus amitriptyline versus amitriptyline	1	−0.76 [−1.16, −0.36]	0.0002
Meta-Analysis [FEM]	14	−0.51 [−0.71, −0.31]	<0.00001
Meta-Analysis [REM]	14	−0.69 [−1.25, −0.13]	0.02

FEM: fixed effects model, REM: random effects model.