Hypoglycemic Activity of Aqueous Extracts from Catharanthus roseus

Table 2

Percentage blood glucose reduction produced by aqueous extracts and a alkaloid-free fraction of Catharanthus roseus after intraperitoneal administration in alloxan-induced diabetic mice.

Treatment (𝑛=6)	Dose	Fast blood glucose (mg/dL)		Percent blood glucose reduction
			2 h	4 h	6 h
Control	6.6 (mL/Kg)	542±33.068	−0.21±0.4	6.88±1.35	−2.4±0.427
Tolbutamide	125 (mg/Kg)	537±36.74	40.78±3.76^∗	46.92±4.37^∗	58.1±8.54^∗
Aq. flower	250 (mg/Kg)	568±85	22.83±1.88	44.60±11.73^∗	51.68±15.84^∗
Aq. root	250 (mg/Kg)	378±36.74	24.29±3.09	35.00±2.94	47.61±5.34^∗
Aq. leaf	250 (mg/Kg)	541±40.41	5.73±0.63	23.99±3.90	41.25±7.38^∗
Aq. stem	250 (mg/Kg)	391±39.19	26.59±6.57	50.72±4.73^∗	52.94±5.96^∗
Alkaloid-free stem fraction	300 (mg/Kg)	537±10.20	32.57±2.48	34.63±2.70	51.21±4.25^∗

Values are mean percent blood glucose reduction (±S.E.M.). *Significant differences from glycemia in fasting (𝑃<0.05). 𝑛=6.