Effects of a Chinese Herbal Medicine, Guan-Jen-Huang (Aeginetia indica Linn.), on Renal Cancer Cell Growth and Metastasis

Figure 3

Antimetastatic effect of GJH on 786-O cells. GJH (1.3–5.0 mg/mL) significantly reduced the (a) adhesion of 786-O cells to HUVECs, the (b) migration and (c) invasion of 786-O cells. (d) Animal experiments showed that oral administration of GJH (25 g/kg per day for a total of 30 days) significantly reduces metastatic tumor nodules in the lungs as demonstrated by lung weight. (e) There was no significant difference in body weight between mice treated with (open circle) and without (closed circle) GJH. The mean (SD) is shown from at least 3 experiments. *𝑃<0.05,**𝑃<0.01,***𝑃<0.001.

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