Zerumbone, a Southeast Asian Ginger Sesquiterpene, Induced Apoptosis of Pancreatic Carcinoma Cells through p53 Signaling Pathway

Figure 5

Effects of zerumbone on the expression of p53 and miR-34. (a) Zerumbone 30 μM markedly inhibited the p53, p21, and PUMA protein expression. (b) Zerumbone 30 μM decreased the miR-34 level. (c) The p53 specific inhibitor pifithrin α reversed the inhibitory influences of zerumbone on cellular viability. 𝑛=3 independent experiments, ^∗𝑃<0.05 versus Control, ^#𝑃<0.05 versus Zerumbone.

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