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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 936459, 7 pages
http://dx.doi.org/10.1155/2012/936459
Review Article

Chinese Herbal Medicine Liu Jun Zi Tang and Xiang Sha Liu Jun Zi Tang for Functional Dyspepsia: Meta-Analysis of Randomized Controlled Trials

1Department of Traditional Chinese Medicine, Southern Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangdong, Guangzhou 510515, China
2School of Traditional Chinese Medicine, Southern Medical University, 1838 North Guangzhou Avenue, Guangdong, Guangzhou 510515, China
3Department of Science and Technology, Southern Medical University, 1838 North Guangzhou Avenue, Guangdong, Guangzhou 510515, China

Received 9 August 2012; Revised 15 October 2012; Accepted 26 October 2012

Academic Editor: Il-Moo Chang

Copyright © 2012 Ya Xiao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. To assess the efficacy and safety of Liu Jun Zi Tang (LJZT) and Xiang Sha Liu Jun Zi Tang (XSLJZT) for treating functional dyspepsia. Methods. Literature searches were carried out on Medline database, Cochrane Library, CNKI database, Chinese Biomedical Literature database, Wanfang database, and VIP database up to July 2012. Hand search for further references was conducted. Study selection, data extraction, quality assessment, and data analyses were performed according to the Cochrane standards. Results. Fifteen publications in total were suitable for inclusion. There was evidence that LJZT compared with prokinetic drugs increased symptom improvement (odds ratio 1.96, 95% CI 1.15 to 3.36). There was also evidence that XSLJZT compared with prokinetic drugs increased symptom improvement (odds ratio 2.63, 95% CI 1.72 to 4.03). No adverse events were reported in LJZT or XSLJZT group in any of these randomized controlled trials. Conclusion. LJZT and XSLJZT might be more effective compared with prokinetic drugs in the treatment of functional dyspepsia, and no side effects are identified in the included trials. However, due to poor methodological quality in the majority of included studies, the potential benefit from LJZT and XSLJZT need to be confirmed in rigorously designed, multicentre, and large-scale trials.