About this Journal Submit a Manuscript Table of Contents
Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 936459, 7 pages
http://dx.doi.org/10.1155/2012/936459
Review Article

Chinese Herbal Medicine Liu Jun Zi Tang and Xiang Sha Liu Jun Zi Tang for Functional Dyspepsia: Meta-Analysis of Randomized Controlled Trials

1Department of Traditional Chinese Medicine, Southern Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangdong, Guangzhou 510515, China
2School of Traditional Chinese Medicine, Southern Medical University, 1838 North Guangzhou Avenue, Guangdong, Guangzhou 510515, China
3Department of Science and Technology, Southern Medical University, 1838 North Guangzhou Avenue, Guangdong, Guangzhou 510515, China

Received 9 August 2012; Revised 15 October 2012; Accepted 26 October 2012

Academic Editor: Il-Moo Chang

Copyright © 2012 Ya Xiao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Karamanolis, P. Caenepeel, J. Arts, and J. Tack, “Association of the predominant symptom with clinical characteristics and pathophysiological mechanisms in functional dyspepsia,” Gastroenterology, vol. 130, no. 2, pp. 296–303, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. H. Kusunoki, K. Haruma, J. Hata et al., “Real-time ultrasonographic assessment of antroduodenal motility after ingestion of solid and liquid meals by patients with functional dyspepsia,” Journal of Gastroenterology and Hepatology, vol. 15, no. 9, pp. 1022–1027, 2000. View at Publisher · View at Google Scholar · View at Scopus
  3. B. E. Lacy, N. J. Talley, G. R. Locke, et al., “Review article: current treatment options and management of functional dyspepsia,” Alimentary Pharmacology and Therapeutics, vol. 36, no. 1, pp. 3–15, 2012.
  4. S. Aoki, K. Haruma, H. Kusunoki et al., “Evaluation of gastric emptying measured with the 13C-octanoic acid breath test in patients with functional dyspepsia: comparison with ultrasonography,” Scandinavian Journal of Gastroenterology, vol. 37, no. 6, pp. 662–666, 2002. View at Publisher · View at Google Scholar · View at Scopus
  5. N. J. Talley and S. F. Phillips, “Non-ulcer dyspepsia: potential causes and pathophysiology,” Annals of Internal Medicine, vol. 108, no. 6, pp. 865–879, 1988. View at Scopus
  6. P. Moayyedi, S. Soo, J. Deeks, B. Delaney, M. Innes, and D. Forman, “Pharmacological interventions for non-ulcer dyspepsia,” Cochrane Database of Systematic Reviews, no. 1, p. CD001960, 2003. View at Scopus
  7. D. K. Wysowski, A. Corken, H. Gallo-Torres, L. Talarico, and E. M. Rodriguez, “Postmarketing reports of QT prolongation and ventricular arrhythmia in association with cisapride and Food and Drug Administration regulatory actions,” American Journal of Gastroenterology, vol. 96, no. 6, pp. 1698–1703, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. P. Moayyedi, S. Soo, J. Deeks et al., “Eradication of Helicobacter pylori for non-ulcer dyspepsia,” Cochrane Database of Systematic Reviews, no. 1, p. CD002096, 2003. View at Scopus
  9. W. D. Zhang, B. H. Wei, and Z. S. Chen, “Schedule for diagnosis and treatment of functional indigestion syndrome with intergrative Chinese and Western medicine,” Chinese Journal of Integrated Traditional and Western Medicine, vol. 25, no. 6, pp. 559–561, 2005. View at Scopus
  10. M. Tatsuta and H. Iishi, “Effect of treatment with Liu-Jun-Zi-Tang (TJ-43) on gastric emptying and gastrointestinal symptoms in dyspeptic patients,” Alimentary Pharmacology and Therapeutics, vol. 7, no. 4, pp. 459–462, 1993. View at Scopus
  11. X. R. Li and G. H. Yu, “Pharmacological research and clinical application of xiang sha liu jun zi tang,” Journal of Changchun University of Traditional Chinese Medicine, vol. 24, no. 1, pp. 68–69, 2008.
  12. Chinese Society of Digestive Diseases and Chinese Association of Integrative Medicine, “Consensus on the diagnosis and treatment of functional dyspepsia by Integrated Traditional and Western Medicine,” Chinese Journal of Integrated Traditional and Western Medicine, vol. 31, no. 11, pp. 1545–1549, 2011.
  13. Q. J. Chen, “Clinical observation on modified xiang sha liu jun zi tang treating 65 patients with functional dyspepsia,” Henan Journal of Traditional Chinese Medicine, vol. 25, no. 2, p. 61, 2005.
  14. W. D. Gui, “Clinical observation on modified xiang sha liu jun zi tang treating 40 patients with functional dyspepsia,” Hunan Journal of Traditional Chinese Medicine, vol. 19, no. 4, pp. 15–16, 2003.
  15. J. J. Li, “Clinical observation on effect of modified xiang sha liu jun zi tang in treating 36 patients with functional dyspepsia,” Journal of Handan Medical College, vol. 17, no. 6, pp. 530–531, 2004.
  16. Q. P. Fan, “Clinical observation of functional dyspepsia with modified xiang sha liu jun zi tang,” Chinese Journal of Experimental Traditional Medical Formulae, vol. 16, no. 3, p. 146, 2010.
  17. Q. Y. Lu and W. Hong, “Clinical observation of functional dyspepsia with modified xiang sha liu jun zi tang,” China Journal of Chinese Medicine, vol. 27, no. 164, pp. 91–92, 2012.
  18. R. Q. Chen and Q. Y. Zhang, “Clinical observation on modified liu jun zi tang treating 40 patients with functional dyspepsia,” Shanxi Journal of Traditional Chinese Medicine, vol. 24, no. 7, pp. 12–13, 2008.
  19. Z. Wang, “Clinical observation on effect of modified liu jun zi tang in treating 60 patients with functional dyspepsia,” Heilongjiang Journal of Traditional Chinese Medicine, vol. 5, pp. 23–23, 2010.
  20. M. Arai, T. Matsumura, N. Tsuchiya, et al., “Rikkunshito improves the symptoms in patients with functional dyspepsia, accompanied by an increase in the level of plasma ghrelin,” Hepatogastroenterology, vol. 59, no. 113, pp. 62–66, 2012.
  21. L. L. Xiao, “Effect of treatment with modified xiang sha liu jun zi tang and Cisapride in patients with functional dyspepsia,” Journal of Hunan University of Traditional Chinese Medicine, vol. 25, no. 2, pp. 41–42, 2005.
  22. J. Li, “Clinical observation on xiang sha liu jun zi tang treating 32 patients with functional dyspepsia,” Guiding Journal of Traditional Chinese Medicine and Pharmacy, vol. 16, no. 12, pp. 47–48, 2010.
  23. X. P. Zhang and S. J. Shun, “Effect of treatment with modified liu jun zi tang on plasma motilin in patients with functional dyspepsia,” Journal of Traditional Chinese Medicine, vol. 43, no. 7, pp. 517–519, 2002.
  24. W. G. Zhao and H. X. Che, “Clinical observation on effect of liu jun zi tang in treating 100 patients with functional dyspepsia,” Shanxi Journal of Traditional Chinese Medicine, vol. 30, no. 9, pp. 1178–1179, 2009.
  25. W. Liang, “Clinical observation on modified xiang sha liu jun zi tang treating 30 patients with functional dyspepsia,” Journal of Shanxi College of Traditional Chinese Medicine, vol. 34, no. 2, pp. 48–50, 2011.
  26. Y. P. Zhou, “Clinical observation of functional dyspepsia with xiang sha liu jun zi tang,” Journal of Hunan University of Traditional Chinese Medicine, vol. 12, no. 1, pp. 134–135, 2010.
  27. B. P. Tian and J. Wang, “Clinical observation of functional dyspepsia with liu jun zi tang versus Mosapride,” Chinese Archives of Traditional Chinese Medicine, vol. 23, no. 3, pp. 569–570, 2005.
  28. A. R. Jadad, R. A. Moore, D. Carroll et al., “Assessing the quality of reports of randomized clinical trials: is blinding necessary?” Controlled Clinical Trials, vol. 17, no. 1, pp. 1–12, 1996. View at Publisher · View at Google Scholar · View at Scopus
  29. T. Hayakawa, T. Arakawa, Y. Kase et al., “Liu-Jun-Zi-Tang, a kampo medicine, promotes adaptive relaxation in isolated guinea pig stomachs,” Drugs under Experimental and Clinical Research, vol. 25, no. 5, pp. 211–218, 1999. View at Scopus
  30. T. Kido, Y. Nakai, Y. Kase et al., “Effects of Rikkunshi-to, a traditional Japanese medicine, on the delay of gastric emptying induced by NG-nitro-L-arginine,” Journal of Pharmacological Sciences, vol. 98, no. 2, pp. 161–167, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. T. Matsumura, M. Arai, Y. Yonemitsu et al., “The traditional Japanese medicine Rikkunshito increases the plasma level of ghrelin in humans and mice,” Journal of Gastroenterology, vol. 45, no. 3, pp. 300–307, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. L. Y. Feng, “Effects of xiang sha liu jun zi tang on gastric and intestinal functions in animals,” Chinese Journal of Integrated Traditional and Western Medicine, vol. 12, no. 1, pp. 35–37, 1992. View at Scopus
  33. X. D. Peng and Y. X. Huang, “Effect of xiang sha liu jun pills on electrogastrogram and gastrin in patients with functional dyspepsia,” Shenzhen Journal of Integrated Traditional and Western Medicine, vol. 11, no. 1, pp. 20–24, 2001.
  34. X. Y. Deng, “Experiment research of xiang sha liu jun zi tang on gastric and intestinal functions,” Chinese Traditional Patent Medicine, vol. 13, no. 12, pp. 30–31, 1991.
  35. Y. F. Zhang, T. Z. Zheng, W. Li, et al., “Effects of Xiang Sha Liu Jun Zi Tang and its component on contractile activity of isolated gastric muscle strips in rats,” Journal of Lanzhou Medical College, vol. 25, no. 2, pp. 1–3, 1999.
  36. H. S. Kim, S. P. Parajuli, C. H. Yeum et al., “Effects of ginseng total saponins on pacemaker currents of interstitial cells of Cajal from the small intestine of mice,” Biological and Pharmaceutical Bulletin, vol. 30, no. 11, pp. 2037–2042, 2007. View at Publisher · View at Google Scholar · View at Scopus
  37. D. Chen, C. F. Wu, L. Huang, and Z. Ning, “Effect of the aqueous extract of Xiao-Ban-Xia-Tang on gastric emptying in mice,” American Journal of Chinese Medicine, vol. 30, no. 2-3, pp. 207–214, 2002. View at Publisher · View at Google Scholar · View at Scopus
  38. Y. Okui, M. Morita, A. Iizuka et al., “Effects of Hoelen on the efferent activity of the gastric vagus nerve in the rat,” Japanese Journal of Pharmacology, vol. 72, no. 1, pp. 71–73, 1996. View at Scopus
  39. Y. Nakai, T. Kido, K. Hashimoto et al., “Effect of the rhizomes of Atractylodes lancea and its constituents on the delay of gastric emptying,” Journal of Ethnopharmacology, vol. 84, no. 1, pp. 51–55, 2003. View at Publisher · View at Google Scholar · View at Scopus
  40. G. Chen, L. Zhu, Y. Liu, Q. Zhou, H. Chen, and J. Yang, “Isoliquiritigenin, a flavonoid from licorice, plays a dual role in regulating gastrointestinal motility in vitro and in vivo,” Phytotherapy Research, vol. 23, no. 4, pp. 498–506, 2009. View at Publisher · View at Google Scholar · View at Scopus
  41. S. F. Chen, Y. Q. Li, and F. Y. He, “Effect of Saussurea lappa on gastric functions,” Chinese Journal of Integrated Traditional and Western Medicine, vol. 14, no. 7, pp. 406–408, 1994. View at Scopus